Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3560408..3561045 | Replicon | chromosome |
| Accession | NZ_CP092185 | ||
| Organism | Bacillus velezensis strain K203 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | MF598_RS17745 | Protein ID | WP_003156187.1 |
| Coordinates | 3560408..3560758 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | I2HMS5 |
| Locus tag | MF598_RS17750 | Protein ID | WP_003156188.1 |
| Coordinates | 3560764..3561045 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MF598_RS17705 (MF598_17705) | 3555448..3556050 | - | 603 | WP_082999005.1 | PP2C family serine/threonine-protein phosphatase | - |
| MF598_RS17710 (MF598_17710) | 3556050..3556838 | - | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
| MF598_RS17715 (MF598_17715) | 3556804..3557286 | - | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
| MF598_RS17720 (MF598_17720) | 3557283..3557612 | - | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
| MF598_RS17725 (MF598_17725) | 3557676..3558683 | - | 1008 | WP_044802655.1 | PP2C family protein-serine/threonine phosphatase | - |
| MF598_RS17730 (MF598_17730) | 3558695..3559096 | - | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
| MF598_RS17735 (MF598_17735) | 3559099..3559464 | - | 366 | WP_007609584.1 | RsbT antagonist protein RsbS | - |
| MF598_RS17740 (MF598_17740) | 3559469..3560290 | - | 822 | WP_003156182.1 | STAS domain-containing protein | - |
| MF598_RS17745 (MF598_17745) | 3560408..3560758 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| MF598_RS17750 (MF598_17750) | 3560764..3561045 | - | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| MF598_RS17755 (MF598_17755) | 3561165..3562334 | - | 1170 | WP_038457028.1 | alanine racemase | - |
| MF598_RS17760 (MF598_17760) | 3562451..3563458 | - | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
| MF598_RS17765 (MF598_17765) | 3563623..3563988 | - | 366 | WP_007609580.1 | holo-ACP synthase | - |
| MF598_RS17770 (MF598_17770) | 3564081..3564680 | + | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T235785 WP_003156187.1 NZ_CP092185:c3560758-3560408 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T235785 NZ_LR134354:1759611-1759967 [Bifidobacterium longum subsp. infantis]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGATGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGATGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT235785 WP_003156188.1 NZ_CP092185:c3561045-3560764 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT235785 NZ_LR134354:1759331-1759624 [Bifidobacterium longum subsp. infantis]
ATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCATGGG
GTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCGTCC
GCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCCCAG
ATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA
ATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCATGGG
GTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCGTCC
GCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCCCAG
ATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|