Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 2740050..2740967 | Replicon | chromosome |
| Accession | NZ_CP092185 | ||
| Organism | Bacillus velezensis strain K203 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | I2HQ15 |
| Locus tag | MF598_RS13265 | Protein ID | WP_007407256.1 |
| Coordinates | 2740050..2740796 (+) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | I2HQ14 |
| Locus tag | MF598_RS13270 | Protein ID | WP_003154807.1 |
| Coordinates | 2740797..2740967 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MF598_RS13245 (MF598_13245) | 2735442..2736392 | - | 951 | WP_224224209.1 | ring-cleaving dioxygenase | - |
| MF598_RS13250 (MF598_13250) | 2736715..2738031 | + | 1317 | WP_224224208.1 | amino acid permease | - |
| MF598_RS13255 (MF598_13255) | 2738317..2738934 | + | 618 | WP_032874614.1 | DUF47 domain-containing protein | - |
| MF598_RS13260 (MF598_13260) | 2738947..2739945 | + | 999 | WP_044802872.1 | inorganic phosphate transporter | - |
| MF598_RS13265 (MF598_13265) | 2740050..2740796 | + | 747 | WP_007407256.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| MF598_RS13270 (MF598_13270) | 2740797..2740967 | + | 171 | WP_003154807.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| MF598_RS13275 (MF598_13275) | 2741064..2741189 | + | 126 | WP_003154809.1 | hypothetical protein | - |
| MF598_RS13280 (MF598_13280) | 2741224..2742102 | - | 879 | WP_007407257.1 | N-acetylmuramoyl-L-alanine amidase | - |
| MF598_RS13285 (MF598_13285) | 2742116..2742379 | - | 264 | WP_003154813.1 | phage holin | - |
| MF598_RS13290 (MF598_13290) | 2742393..2742656 | - | 264 | WP_003154815.1 | hemolysin XhlA family protein | - |
| MF598_RS13295 (MF598_13295) | 2742709..2743470 | - | 762 | WP_045207175.1 | hypothetical protein | - |
| MF598_RS13300 (MF598_13300) | 2743527..2743724 | - | 198 | WP_007610833.1 | XkdX family protein | - |
| MF598_RS13305 (MF598_13305) | 2743729..2744100 | - | 372 | WP_032874603.1 | XkdW family protein | - |
| MF598_RS13310 (MF598_13310) | 2744113..2745735 | - | 1623 | WP_224224207.1 | pyocin knob domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2682674..2786437 | 103763 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29077.57 Da Isoelectric Point: 4.7755
>T235784 WP_007407256.1 NZ_CP092185:2740050-2740796 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
Download Length: 747 bp
>T235784 NZ_LR134354:c1687528-1687160 [Bifidobacterium longum subsp. infantis]
ATGACCAGTACGCCAAGTGAACCGCGCCTGTATGACGTGTGGCTGATGTGGGTCGAGTTTCCCGACCATCCCGGTATCGG
CAAGCCGCGTCCCGTGGTAATCACCGAGGTTGACGGTGATCTGGTGTCGGGTATCGTGGCGAAGATAACCGGCAACACTG
ATTGGGATGAGGCCGGCGACGTGCCGCTGCTCGACTGGAAGGCCGAGGGGCTGTTGAAGCCGTCACTCGTGCGCTGTTCG
CAACGCTTCTACTTCAACAGGAGCGAACTGCTGCAATGGTTCGGACGACTCTCGTTGAGGGACGCGGAGCATGTTAACGA
CGGATTGGAAGCCACGTTGGACATTCCACCATACAGGCGGAGCGTATAG
ATGACCAGTACGCCAAGTGAACCGCGCCTGTATGACGTGTGGCTGATGTGGGTCGAGTTTCCCGACCATCCCGGTATCGG
CAAGCCGCGTCCCGTGGTAATCACCGAGGTTGACGGTGATCTGGTGTCGGGTATCGTGGCGAAGATAACCGGCAACACTG
ATTGGGATGAGGCCGGCGACGTGCCGCTGCTCGACTGGAAGGCCGAGGGGCTGTTGAAGCCGTCACTCGTGCGCTGTTCG
CAACGCTTCTACTTCAACAGGAGCGAACTGCTGCAATGGTTCGGACGACTCTCGTTGAGGGACGCGGAGCATGTTAACGA
CGGATTGGAAGCCACGTTGGACATTCCACCATACAGGCGGAGCGTATAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6676.74 Da Isoelectric Point: 10.9273
>AT235784 WP_003154807.1 NZ_CP092185:2740797-2740967 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
Download Length: 171 bp
>AT235784 NZ_LR134354:c1687793-1687509 [Bifidobacterium longum subsp. infantis]
ATGGGTAAGCTGGTCGCCAATATCGATGATGATGTCAAGGCGCGTGCCGCCGCGCTCTACGATTCCATGGGCATGAGCCT
GAGCACCGCAGTCAACATGTTTTTACGCCAGTCTCTGGTGGACAACGGGTTGCCGTTCAAGCCGACGCGGCACACGCCGG
ACGGCTATCCGGTGCCGCCTGTTCACAATGCCTACATGTTCGAGCGTTCGGAGAAGGGCCATGTGATACTGCCCGCCGAT
TGGAATGATTCGGAGGATGCTGTCTATGACCAGTACGCCAAGTGA
ATGGGTAAGCTGGTCGCCAATATCGATGATGATGTCAAGGCGCGTGCCGCCGCGCTCTACGATTCCATGGGCATGAGCCT
GAGCACCGCAGTCAACATGTTTTTACGCCAGTCTCTGGTGGACAACGGGTTGCCGTTCAAGCCGACGCGGCACACGCCGG
ACGGCTATCCGGTGCCGCCTGTTCACAATGCCTACATGTTCGAGCGTTCGGAGAAGGGCCATGTGATACTGCCCGCCGAT
TGGAATGATTCGGAGGATGCTGTCTATGACCAGTACGCCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|