Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3900352..3901008 Replicon chromosome
Accession NZ_CP092184
Organism Serratia marcescens strain YHYF1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MF265_RS18910 Protein ID WP_021504433.1
Coordinates 3900352..3900741 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag MF265_RS18915 Protein ID WP_004941563.1
Coordinates 3900745..3901008 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF265_RS18895 (MF265_18895) 3896820..3898250 + 1431 WP_016926706.1 multidrug transporter subunit MdtD -
MF265_RS18900 (MF265_18900) 3898247..3899629 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
MF265_RS18905 (MF265_18905) 3899629..3900345 + 717 WP_004941568.1 two-component system response regulator BaeR -
MF265_RS18910 (MF265_18910) 3900352..3900741 - 390 WP_021504433.1 type II toxin-antitoxin system VapC family toxin Toxin
MF265_RS18915 (MF265_18915) 3900745..3901008 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MF265_RS18920 (MF265_18920) 3901346..3901684 + 339 WP_004941561.1 YegP family protein -
MF265_RS18925 (MF265_18925) 3901863..3903215 + 1353 WP_049299962.1 tRNA 5-hydroxyuridine modification protein YegQ -
MF265_RS18930 (MF265_18930) 3903683..3904588 + 906 WP_143779312.1 lipid kinase YegS -
MF265_RS18935 (MF265_18935) 3904757..3905971 + 1215 WP_016926700.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14398.63 Da        Isoelectric Point: 8.4983

>T235778 WP_021504433.1 NZ_CP092184:c3900741-3900352 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T235778 NZ_LR134352:c1166575-1166306 [Nocardia asteroides]
ATGCCTGAACGCAAGCTGGCCTTCAGCGCCTACGGGTGGGAGACCTACACATCGTGGCTGGTTCGCGACCGCACGGTCCT
AAAAGCGGCCAACAAAGTGATCGCCGCCGCGCTCGCCGACCCATTCGCCGGGATCGGTAAGCCTGAGCCGTTGAAGCACC
ATCTCGCCGGCCACTGGTCGCGCCGGGTCACCCGCGAGCATCGAATGATCTACTACGTCACCGATTCCGAGATCGTTGTC
ATCGCGGTCGGCGGGCACTACGACGAGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT235778 WP_004941563.1 NZ_CP092184:c3901008-3900745 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT235778 NZ_LR134352:c1166825-1166568 [Nocardia asteroides]
ATGACTGCGCTACCGATTTCCACCGCCCGCCAGAACCTCTTCAAGCTGGTTCAGCAGGTCAACGACGACCACGACACGGT
CACCGTTGTCACCAAGTCGGGCGAGAACGCCGTGCTCGTCGCCGAATCGGATTGGAACTCCATTCAGGAGACGCTGTATG
TTCTCGCCACCCACGGCGGCGTACGACTGCTCGAGTCCGCCCGAGATGCCCGCGAGGGCCGATTCGAGGCACACGAGCTG
ATAGATCCCGATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References