Detailed information of TA system TA023577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 34437..35062
• Replicon: plasmid pSPCV
• Accession: NC_012124
• Organism: Salmonella enterica subsp. enterica serovar Paratyphi C strain

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SPC_RS23830
• Protein ID: WP_000911322.1
• Coordinates: 34664..35062 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8F2UQ48
• Locus tag: SPC_RS23825
• Protein ID: WP_000450263.1
• Coordinates: 34437..34664 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPC_RS23825	34437..34664	+	228	WP_000450263.1	toxin-antitoxin system antitoxin VapB	Antitoxin
SPC_RS23830	34664..35062	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
SPC_RS23835	35071..37314	-	2244	WP_000009314.1	type IV conjugative transfer system coupling protein TraD	-
SPC_RS23840	37686..38417	-	732	WP_000782436.1	complement resistance protein TraT	-
SPC_RS23950	38720..38962	-	243	WP_000632200.1	hypothetical protein	-
SPC_RS23850	38959..39660	-	702	WP_148201696.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55414	55414

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-81)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T23577 WP_000911322.1 NC_012124:34664-35062 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T23577 NC_012124:34664-35062 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT23577 WP_000450263.1 NC_012124:34437-34664 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT23577 NC_012124:34437-34664 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA