Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1386847..1387440 Replicon chromosome
Accession NZ_CP092184
Organism Serratia marcescens strain YHYF1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MF265_RS06675 Protein ID WP_239044335.1
Coordinates 1387150..1387440 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MF265_RS06670 Protein ID WP_239044334.1
Coordinates 1386847..1387140 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF265_RS06640 (MF265_06640) 1382006..1382266 + 261 WP_239044328.1 DUF4752 family protein -
MF265_RS06645 (MF265_06645) 1382268..1382432 + 165 WP_239044329.1 hypothetical protein -
MF265_RS06650 (MF265_06650) 1382537..1383274 + 738 WP_239044330.1 head fiber protein -
MF265_RS06655 (MF265_06655) 1383403..1383987 + 585 WP_239044331.1 terminase small subunit -
MF265_RS06660 (MF265_06660) 1384268..1386517 + 2250 WP_239044332.1 lytic transglycosylase domain-containing protein -
MF265_RS06665 (MF265_06665) 1386522..1386794 + 273 WP_239044333.1 DUF4282 domain-containing protein -
MF265_RS06670 (MF265_06670) 1386847..1387140 - 294 WP_239044334.1 putative addiction module antidote protein Antitoxin
MF265_RS06675 (MF265_06675) 1387150..1387440 - 291 WP_239044335.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MF265_RS06680 (MF265_06680) 1387538..1389007 + 1470 WP_239044336.1 hypothetical protein -
MF265_RS06685 (MF265_06685) 1389010..1389423 + 414 WP_239044337.1 tail fiber assembly protein -
MF265_RS06690 (MF265_06690) 1390091..1391236 - 1146 WP_239044338.1 fucose-binding lectin II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1383174..1561239 178065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10886.35 Da        Isoelectric Point: 5.8552

>T235765 WP_239044335.1 NZ_CP092184:c1387440-1387150 [Serratia marcescens]
MKIIYTTEEFDSWFTGLRDRQAQKRIQTRIDRAEGGNFGDCEPVGEGVSEMRIHYGPGYRVYFVQQGMEIVILLAGGDKS
TQSKDIKAALELARQL

Download         Length: 291 bp

>T235765 NZ_LR134351:c1294371-1294120 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10376.84 Da        Isoelectric Point: 6.2191

>AT235765 WP_239044334.1 NZ_CP092184:c1387140-1386847 [Serratia marcescens]
MGTLKLRKWDSAEHLNSDEDIVAYLEACMEEAGDDAAFIAKALGNIARARGMTQLAKETGVGRESLYKALSGEGNPSFGT
ILKVMHALGLRLHTTAA

Download         Length: 294 bp

>AT235765 NZ_LR134351:c1294130-1293948 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References