Detailed information of TA system TA235763

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 595849..596552
• Replicon: chromosome
• Accession: NZ_CP092184
• Organism: Serratia marcescens strain YHYF1

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: MF265_RS02775
• Protein ID: WP_239044204.1
• Coordinates: 596211..596552 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: MF265_RS02770
• Protein ID: WP_072000044.1
• Coordinates: 595849..596190 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF265_RS02735 (MF265_02735)	591537..591989	+	453	WP_000734321.1	hypothetical protein	-
MF265_RS02740 (MF265_02740)	592061..592333	+	273	Protein_519	hypothetical protein	-
MF265_RS02750 (MF265_02750)	593664..593870	+	207	Protein_521	hypothetical protein	-
MF265_RS02755 (MF265_02755)	593991..594812	+	822	WP_123907369.1	DUF932 domain-containing protein	-
MF265_RS02760 (MF265_02760)	594843..595283	+	441	WP_239044202.1	antirestriction protein	-
MF265_RS02765 (MF265_02765)	595296..595838	+	543	WP_239044203.1	DNA repair protein RadC	-
MF265_RS02770 (MF265_02770)	595849..596190	+	342	WP_072000044.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MF265_RS02775 (MF265_02775)	596211..596552	+	342	WP_239044204.1	TA system toxin CbtA family protein	Toxin
MF265_RS02780 (MF265_02780)	596811..597818	+	1008	WP_032439165.1	restriction endonuclease	-
MF265_RS02785 (MF265_02785)	598456..599574	-	1119	WP_239044205.1	HNH endonuclease signature motif containing protein	-
MF265_RS02790 (MF265_02790)	599810..600118	-	309	WP_115435473.1	hypothetical protein	-
MF265_RS02795 (MF265_02795)	600013..600255	-	243	WP_115435474.1	ash family protein	-
MF265_RS02800 (MF265_02800)	600655..601188	+	534	WP_206195132.1	type IV secretion protein Rhs	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	593204..593572	368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12793.77 Da
• Isoelectric Point: 8.0324

>T235763 WP_239044204.1 NZ_CP092184:596211-596552 [Serratia marcescens]
MKTLPATNPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDEMVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRTVDILRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T235763 NZ_LR134351:718374-718481 [Staphylococcus aureus]
GTGATATCTATTGCAAACGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12683.37 Da
• Isoelectric Point: 6.7300

>AT235763 WP_072000044.1 NZ_CP092184:595849-596190 [Serratia marcescens]
MKSTDSESDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDAAFPHFICQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Nucleotide

• Length: 342 bp

>AT235763 NZ_LR134351:c718590-718476 [Staphylococcus aureus]
TAAAAAGACGACATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGACTAAATGAGATTTTCTTTAACCAT
CATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT