Detailed information of TA system TA235762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 322744..324085
• Replicon: chromosome
• Accession: NZ_CP092184
• Organism: Serratia marcescens strain YHYF1

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: MF265_RS01420
• Protein ID: WP_239044099.1
• Coordinates: 322744..323697 (-)
• Length: 318 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: MF265_RS01425
• Protein ID: WP_239044100.1
• Coordinates: 323690..324085 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF265_RS01390 (MF265_01390)	317886..318395	+	510	WP_065426406.1	fimbrial protein	-
MF265_RS01395 (MF265_01395)	318407..318892	+	486	WP_161801396.1	fimbrial protein	-
MF265_RS01400 (MF265_01400)	318947..319471	+	525	WP_239044097.1	fimbrial protein	-
MF265_RS01405 (MF265_01405)	319597..320415	+	819	WP_239044098.1	hypothetical protein	-
MF265_RS01410 (MF265_01410)	320655..321185	+	531	WP_049299755.1	LuxR family transcriptional regulator	-
MF265_RS01415 (MF265_01415)	321697..321984	+	288	WP_049299754.1	hypothetical protein	-
MF265_RS01420 (MF265_01420)	322744..323697	-	954	WP_239044099.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MF265_RS01425 (MF265_01425)	323690..324085	-	396	WP_239044100.1	DUF6088 family protein	Antitoxin
MF265_RS01430 (MF265_01430)	324160..324993	-	834	WP_239044101.1	DUF4942 domain-containing protein	-
MF265_RS01435 (MF265_01435)	325522..327141	+	1620	WP_239044102.1	ISL3 family transposase	-
MF265_RS01440 (MF265_01440)	327157..327231	+	75	Protein_266	hypothetical protein	-
MF265_RS01445 (MF265_01445)	327284..327700	+	417	Protein_267	recombinase family protein	-
MF265_RS01450 (MF265_01450)	327728..328057	-	330	WP_239044103.1	LptA/OstA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-293)

Antitoxin

• Protein of unknown function DUF6088 (7-110)

Sequences

Toxin

Protein

• Length: 318 a.a.
• Molecular weight: 35788.34 Da
• Isoelectric Point: 5.4360

>T235762 WP_239044099.1 NZ_CP092184:c323697-322744 [Serratia marcescens]
MDDLTTLFSEVADALGIESVAIVEKDHYILELLALLKPLSFCTHQLVFAGGTALAKSGVLLNRMSEDVDIKMVPTAAFLT
LSRTRRKTSRKAVIQSIIDAITATDMFSVDDGQQVTRDEYRYNDIPVRYPQRLAQEPCLRPFIKLELMEADLLEPAEARD
INSLATGLLKKPPVVQAFPSVTVTSTQAEKLVAMLRRTAAVIRNVERFDDTTLVRHIYDTWCIMHASHVDMALLPVFVER
TINQDIQRYGNQYPQFCDSPVAELKLGLEELENNPVHKERYQQFVAPMVFGKQVTWVEAYGCFRQVALSILDTLPAR

Nucleotide

• Length: 954 bp

>T235762 NZ_LR134351:c562237-562049 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14485.74 Da
• Isoelectric Point: 11.4559

>AT235762 WP_239044100.1 NZ_CP092184:c324085-323690 [Serratia marcescens]
MTTKARIQSRLKRSKRYVFTRDDFKDIAGYDQIGRALRALVKEGELLKVGYGVYTKARRNSITGRIMPASPGGSAAVIVE
TLDRLKVRYRFTDATLAYNSGQSTQVPVSAGIKTPSRFKRVLSVGNSKLNG

Nucleotide

• Length: 396 bp

>AT235762 NZ_LR134351:c562526-562266 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA