Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1424587..1425103 Replicon chromosome
Accession NZ_CP092182
Organism Alcaligenes faecalis strain T17

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MF263_RS06495 Protein ID WP_239055329.1
Coordinates 1424924..1425103 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MF263_RS06490 Protein ID WP_203144927.1
Coordinates 1424587..1424880 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF263_RS06450 (MF263_06450) 1419758..1419904 + 147 WP_239055327.1 hypothetical protein -
MF263_RS06455 (MF263_06455) 1419901..1420074 + 174 WP_238441675.1 hypothetical protein -
MF263_RS06460 (MF263_06460) 1420138..1420479 + 342 WP_238441674.1 hypothetical protein -
MF263_RS06465 (MF263_06465) 1420619..1421116 - 498 WP_238441673.1 BON domain-containing protein -
MF263_RS06470 (MF263_06470) 1422029..1422196 + 168 WP_203144930.1 hypothetical protein -
MF263_RS06475 (MF263_06475) 1423167..1423319 - 153 WP_181363933.1 hypothetical protein -
MF263_RS06480 (MF263_06480) 1423398..1423631 - 234 WP_203144929.1 hypothetical protein -
MF263_RS06485 (MF263_06485) 1423881..1424159 + 279 WP_239055328.1 hypothetical protein -
MF263_RS06490 (MF263_06490) 1424587..1424880 - 294 WP_203144927.1 putative addiction module antidote protein Antitoxin
MF263_RS06495 (MF263_06495) 1424924..1425103 - 180 WP_239055329.1 hypothetical protein Toxin
MF263_RS06500 (MF263_06500) 1425371..1426369 + 999 WP_239055330.1 taurine ABC transporter substrate-binding protein -
MF263_RS06505 (MF263_06505) 1426375..1427160 + 786 Protein_1264 taurine ABC transporter ATP-binding subunit -
MF263_RS06510 (MF263_06510) 1427177..1428067 + 891 WP_239055331.1 taurine ABC transporter permease TauC -
MF263_RS06515 (MF263_06515) 1428326..1429030 - 705 WP_239055332.1 SDR family oxidoreductase -
MF263_RS06520 (MF263_06520) 1429135..1430007 + 873 WP_239055333.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1419596..1430194 10598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-58)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6531.46 Da        Isoelectric Point: 10.1855

>T235761 WP_239055329.1 NZ_CP092182:c1425103-1424924 [Alcaligenes faecalis]
VVRIKQASLGNFGDVKPISDGVSEMRIHFGPGYRLYYAREGRVVYLLLSGGDKSSQNKT

Download         Length: 180 bp

>T235761 NZ_LR134351:11423-11599 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10296.84 Da        Isoelectric Point: 4.8359

>AT235761 WP_203144927.1 NZ_CP092182:c1424880-1424587 [Alcaligenes faecalis]
MTAIKTAPFDAAEYLDSEESIAEYLSAALEEDDPALFLSALADVVKARGMTKMAKDAGVGRESLYKALAPGAKPRYDTVL
KLARAAGVKLTVEPLHA

Download         Length: 294 bp

>AT235761 NZ_LR134351:c11761-11587 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References