Detailed information of TA system TA023576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 11686..12211
• Replicon: plasmid pSPCV
• Accession: NC_012124
• Organism: Salmonella enterica subsp. enterica serovar Paratyphi C strain

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: SPC_RS23700
• Protein ID: WP_001159863.1
• Coordinates: 11686..11991 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: SPC_RS23705
• Protein ID: WP_000813641.1
• Coordinates: 11993..12211 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPC_RS23660	7067..7626	-	560	Protein_9	inverse autotransporter beta domain-containing protein	-
SPC_RS23670	8346..8831	-	486	WP_000905606.1	membrane protein	-
SPC_RS23675	8825..9334	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
SPC_RS23680	9338..10051	-	714	Protein_12	EAL domain-containing protein	-
SPC_RS23685	10060..10842	-	783	WP_000082169.1	site-specific integrase	-
SPC_RS23690	10855..11397	-	543	WP_000198609.1	hypothetical protein	-
SPC_RS23695	11394..11684	-	291	WP_001266176.1	hypothetical protein	-
SPC_RS23700	11686..11991	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
SPC_RS23705	11993..12211	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SPC_RS23710	12886..13407	+	522	WP_077906344.1	hypothetical protein	-
SPC_RS26645	13451..13879	-	429	Protein_19	hypothetical protein	-
SPC_RS25960	13891..14186	+	296	Protein_20	cytoplasmic protein	-
SPC_RS23725	14680..15669	+	990	WP_000461383.1	RepB family plasmid replication initiator protein	-
SPC_RS25475	15787..15948	-	162	WP_001541548.1	hypothetical protein	-
SPC_RS23730	16001..16387	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
SPC_RS26510	16754..17065	-	312	WP_015899541.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55414	55414

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-73)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T23576 WP_001159863.1 NC_012124:c11991-11686 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T23576 NC_012124:c11991-11686 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT23576 WP_000813641.1 NC_012124:c12211-11993 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT23576 NC_012124:c12211-11993 [Salmonella enterica subsp. enterica serovar Paratyphi C str.]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6