Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1840490..1840975 Replicon chromosome
Accession NZ_CP092179
Organism Macrococcus brunensis strain 18KM571

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MGG13_RS09735 Protein ID WP_133432177.1
Coordinates 1840490..1840831 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MGG13_RS09740 Protein ID WP_133432176.1
Coordinates 1840832..1840975 (-) Length 48 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGG13_RS09710 (MGG13_09710) 1835571..1837712 - 2142 WP_239034745.1 Tex family protein -
MGG13_RS09715 (MGG13_09715) 1837774..1838550 - 777 WP_239034746.1 RNA polymerase sigma factor SigB -
MGG13_RS09720 (MGG13_09720) 1838525..1838998 - 474 WP_133432844.1 anti-sigma B factor RsbW -
MGG13_RS09725 (MGG13_09725) 1839000..1839323 - 324 WP_239034747.1 anti-sigma factor antagonist -
MGG13_RS09730 (MGG13_09730) 1839412..1840410 - 999 WP_239035715.1 PP2C family protein-serine/threonine phosphatase -
MGG13_RS09735 (MGG13_09735) 1840490..1840831 - 342 WP_133432177.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MGG13_RS09740 (MGG13_09740) 1840832..1840975 - 144 WP_133432176.1 antitoxin MazE Antitoxin
MGG13_RS09745 (MGG13_09745) 1841035..1842165 - 1131 WP_239034748.1 alanine racemase -
MGG13_RS09750 (MGG13_09750) 1842179..1842526 - 348 WP_133432174.1 holo-ACP synthase -
MGG13_RS09755 (MGG13_09755) 1842523..1842996 - 474 WP_133432173.1 PH domain-containing protein -
MGG13_RS09760 (MGG13_09760) 1842983..1844455 - 1473 WP_239034749.1 PH domain-containing protein -
MGG13_RS09765 (MGG13_09765) 1844448..1844924 - 477 WP_133432171.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12500.54 Da        Isoelectric Point: 10.0505

>T235756 WP_133432177.1 NZ_CP092179:c1840831-1840490 [Macrococcus brunensis]
MRRGEVFLADLSPVKGSEQGGKRPVVIIQNDVGNKYSPTVIVAAITAKINKARIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTVLSAEKMHEVNQALEISLGLTQ

Download         Length: 342 bp

>T235756 NZ_LR134342:c3115563-3115282 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 48 a.a.        Molecular weight: 5519.13 Da        Isoelectric Point: 3.6003

>AT235756 WP_133432176.1 NZ_CP092179:c1840975-1840832 [Macrococcus brunensis]
MKKFDQLLAEGYESMAELNLIISYEQFDLESEVCEKSEMYFLSDDGE

Download         Length: 144 bp

>AT235756 NZ_LR134342:c3115787-3115560 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References