Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1908332..1908817 | Replicon | chromosome |
| Accession | NZ_CP092172 | ||
| Organism | Macrococcus brunensis strain 18KM1742 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | MGG12_RS10215 | Protein ID | WP_133432177.1 |
| Coordinates | 1908332..1908673 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | MGG12_RS10220 | Protein ID | WP_239047262.1 |
| Coordinates | 1908674..1908817 (-) | Length | 48 a.a. |
Genomic Context
Location: 1903413..1905554 (2142 bp)
Type: Others
Protein ID: WP_239047259.1
Type: Others
Protein ID: WP_239047259.1
Location: 1905616..1906392 (777 bp)
Type: Others
Protein ID: WP_239034746.1
Type: Others
Protein ID: WP_239034746.1
Location: 1906367..1906840 (474 bp)
Type: Others
Protein ID: WP_239047260.1
Type: Others
Protein ID: WP_239047260.1
Location: 1906842..1907165 (324 bp)
Type: Others
Protein ID: WP_239047261.1
Type: Others
Protein ID: WP_239047261.1
Location: 1907254..1908252 (999 bp)
Type: Others
Protein ID: WP_239035715.1
Type: Others
Protein ID: WP_239035715.1
Location: 1908332..1908673 (342 bp)
Type: Toxin
Protein ID: WP_133432177.1
Type: Toxin
Protein ID: WP_133432177.1
Location: 1908674..1908817 (144 bp)
Type: Antitoxin
Protein ID: WP_239047262.1
Type: Antitoxin
Protein ID: WP_239047262.1
Location: 1908877..1910007 (1131 bp)
Type: Others
Protein ID: WP_239034748.1
Type: Others
Protein ID: WP_239034748.1
Location: 1910021..1910368 (348 bp)
Type: Others
Protein ID: WP_239047263.1
Type: Others
Protein ID: WP_239047263.1
Location: 1910365..1910838 (474 bp)
Type: Others
Protein ID: WP_133432173.1
Type: Others
Protein ID: WP_133432173.1
Location: 1910825..1912297 (1473 bp)
Type: Others
Protein ID: WP_239034749.1
Type: Others
Protein ID: WP_239034749.1
Location: 1912290..1912766 (477 bp)
Type: Others
Protein ID: WP_133432171.1
Type: Others
Protein ID: WP_133432171.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MGG12_RS10190 (MGG12_10190) | 1903413..1905554 | - | 2142 | WP_239047259.1 | Tex family protein | - |
| MGG12_RS10195 (MGG12_10195) | 1905616..1906392 | - | 777 | WP_239034746.1 | RNA polymerase sigma factor SigB | - |
| MGG12_RS10200 (MGG12_10200) | 1906367..1906840 | - | 474 | WP_239047260.1 | anti-sigma B factor RsbW | - |
| MGG12_RS10205 (MGG12_10205) | 1906842..1907165 | - | 324 | WP_239047261.1 | anti-sigma factor antagonist | - |
| MGG12_RS10210 (MGG12_10210) | 1907254..1908252 | - | 999 | WP_239035715.1 | PP2C family protein-serine/threonine phosphatase | - |
| MGG12_RS10215 (MGG12_10215) | 1908332..1908673 | - | 342 | WP_133432177.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MGG12_RS10220 (MGG12_10220) | 1908674..1908817 | - | 144 | WP_239047262.1 | hypothetical protein | Antitoxin |
| MGG12_RS10225 (MGG12_10225) | 1908877..1910007 | - | 1131 | WP_239034748.1 | alanine racemase | - |
| MGG12_RS10230 (MGG12_10230) | 1910021..1910368 | - | 348 | WP_239047263.1 | holo-ACP synthase | - |
| MGG12_RS10235 (MGG12_10235) | 1910365..1910838 | - | 474 | WP_133432173.1 | PH domain-containing protein | - |
| MGG12_RS10240 (MGG12_10240) | 1910825..1912297 | - | 1473 | WP_239034749.1 | PH domain-containing protein | - |
| MGG12_RS10245 (MGG12_10245) | 1912290..1912766 | - | 477 | WP_133432171.1 | PH domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12500.54 Da Isoelectric Point: 10.0505
>T235755 WP_133432177.1 NZ_CP092172:c1908673-1908332 [Macrococcus brunensis]
MRRGEVFLADLSPVKGSEQGGKRPVVIIQNDVGNKYSPTVIVAAITAKINKARIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTVLSAEKMHEVNQALEISLGLTQ
MRRGEVFLADLSPVKGSEQGGKRPVVIIQNDVGNKYSPTVIVAAITAKINKARIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTVLSAEKMHEVNQALEISLGLTQ
Download Length: 342 bp
>T235755 NZ_LR134342:c1945557-1945279 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 48 a.a. Molecular weight: 5505.10 Da Isoelectric Point: 3.5858
>AT235755 WP_239047262.1 NZ_CP092172:c1908817-1908674 [Macrococcus brunensis]
MKKFDQLLADGYESMAELNLIISYEQFDLESEVCEKSEMYFLSDDGE
MKKFDQLLADGYESMAELNLIISYEQFDLESEVCEKSEMYFLSDDGE
Download Length: 144 bp
>AT235755 NZ_LR134342:c1945267-1944962 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG