Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1908332..1908817 Replicon chromosome
Accession NZ_CP092172
Organism Macrococcus brunensis strain 18KM1742

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MGG12_RS10215 Protein ID WP_133432177.1
Coordinates 1908332..1908673 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MGG12_RS10220 Protein ID WP_239047262.1
Coordinates 1908674..1908817 (-) Length 48 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGG12_RS10190 (MGG12_10190) 1903413..1905554 - 2142 WP_239047259.1 Tex family protein -
MGG12_RS10195 (MGG12_10195) 1905616..1906392 - 777 WP_239034746.1 RNA polymerase sigma factor SigB -
MGG12_RS10200 (MGG12_10200) 1906367..1906840 - 474 WP_239047260.1 anti-sigma B factor RsbW -
MGG12_RS10205 (MGG12_10205) 1906842..1907165 - 324 WP_239047261.1 anti-sigma factor antagonist -
MGG12_RS10210 (MGG12_10210) 1907254..1908252 - 999 WP_239035715.1 PP2C family protein-serine/threonine phosphatase -
MGG12_RS10215 (MGG12_10215) 1908332..1908673 - 342 WP_133432177.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MGG12_RS10220 (MGG12_10220) 1908674..1908817 - 144 WP_239047262.1 hypothetical protein Antitoxin
MGG12_RS10225 (MGG12_10225) 1908877..1910007 - 1131 WP_239034748.1 alanine racemase -
MGG12_RS10230 (MGG12_10230) 1910021..1910368 - 348 WP_239047263.1 holo-ACP synthase -
MGG12_RS10235 (MGG12_10235) 1910365..1910838 - 474 WP_133432173.1 PH domain-containing protein -
MGG12_RS10240 (MGG12_10240) 1910825..1912297 - 1473 WP_239034749.1 PH domain-containing protein -
MGG12_RS10245 (MGG12_10245) 1912290..1912766 - 477 WP_133432171.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12500.54 Da        Isoelectric Point: 10.0505

>T235755 WP_133432177.1 NZ_CP092172:c1908673-1908332 [Macrococcus brunensis]
MRRGEVFLADLSPVKGSEQGGKRPVVIIQNDVGNKYSPTVIVAAITAKINKARIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTVLSAEKMHEVNQALEISLGLTQ

Download         Length: 342 bp

>T235755 NZ_LR134342:c1945557-1945279 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 48 a.a.        Molecular weight: 5505.10 Da        Isoelectric Point: 3.5858

>AT235755 WP_239047262.1 NZ_CP092172:c1908817-1908674 [Macrococcus brunensis]
MKKFDQLLADGYESMAELNLIISYEQFDLESEVCEKSEMYFLSDDGE

Download         Length: 144 bp

>AT235755 NZ_LR134342:c1945267-1944962 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References