Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1610187..1610698 Replicon chromosome
Accession NC_012121
Organism Staphylococcus carnosus subsp. carnosus TM300

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag SCA_RS08060 Protein ID WP_015900832.1
Coordinates 1610187..1610393 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag SCA_RS08065 Protein ID WP_015900833.1
Coordinates 1610405..1610698 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCA_RS08045 1606160..1607377 + 1218 WP_015900829.1 rod shape-determining protein RodA -
SCA_RS12925 1607449..1607589 - 141 WP_167313208.1 hypothetical protein -
SCA_RS08050 1607665..1609866 - 2202 WP_015900830.1 heavy metal translocating P-type ATPase -
SCA_RS08055 1609963..1610172 - 210 WP_015900831.1 copper ion binding protein -
SCA_RS08060 1610187..1610393 - 207 WP_015900832.1 cation transporter Toxin
SCA_RS08065 1610405..1610698 - 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
SCA_RS08070 1610863..1612344 + 1482 WP_015900834.1 cardiolipin synthase -
SCA_RS08075 1612369..1613016 + 648 WP_015900835.1 HD domain-containing protein -
SCA_RS08080 1613107..1613619 - 513 WP_015900836.1 GNAT family N-acetyltransferase -
SCA_RS08085 1613730..1614599 - 870 WP_015900837.1 membrane protein insertase YidC -
SCA_RS08090 1614688..1615326 - 639 WP_015900838.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T23575 WP_015900832.1 NC_012121:c1610393-1610187 [Staphylococcus carnosus subsp. carnosus TM300]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T23575 NC_012121:c1610393-1610187 [Staphylococcus carnosus subsp. carnosus TM300]
ATGCAAAATAGTGTAATTAAAATTGATGGAATGGAAACTGAAGAAGAACAGCATAAATTGCATCAACATCTTATAGAAAT
GACAGGTGTATCTGCAGTGCAAGTGGATATGGATTCAAATGAAGTCAGAATCAGTTATGAAACACCTGTAAATCTCAATA
ATCTTGAAAAAGAAATCTATGATGCAGGTTATCAAATATTAAATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT23575 WP_015900833.1 NC_012121:c1610698-1610405 [Staphylococcus carnosus subsp. carnosus TM300]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT23575 NC_012121:c1610698-1610405 [Staphylococcus carnosus subsp. carnosus TM300]
ATGACCGAAAATGATAAAGCGCACCATTCAGAACAAATCAAATCCAACTTGAAAGCACGACTCAATCGAATTGAAGGACA
AGTCAGAGCAATTAACCGAATGATTGAAGAGGATGTATATTGTGATGATGTACTCACACAAATCCGTGCAACACGTTCAG
CTTTGAACAGTGTGGCAGTACGATTGCTTGATCATCACATGAAAGGTTGTATCATGCATAAAGTTGAGGATGGTCACGCT
GAAGAAGCGATGGAAGAATTGCTTGTTACCGTTCAAAAATTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References