Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 4294286..4294862 Replicon chromosome
Accession NZ_CP092161
Organism Leptospira interrogans strain FMAS_AP5

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag FH593_RS17775 Protein ID WP_000617908.1
Coordinates 4294286..4294627 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag FH593_RS17780 Protein ID WP_000844758.1
Coordinates 4294614..4294862 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH593_RS17755 (FH593_17755) 4289520..4289924 - 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -
FH593_RS17760 (FH593_17760) 4289921..4290388 - 468 WP_000060053.1 hypothetical protein -
FH593_RS17765 (FH593_17765) 4291192..4292127 + 936 WP_000004530.1 ornithine carbamoyltransferase -
FH593_RS17770 (FH593_17770) 4292267..4293259 + 993 WP_000041093.1 aldolase/citrate lyase family protein -
FH593_RS17775 (FH593_17775) 4294286..4294627 - 342 WP_000617908.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FH593_RS17780 (FH593_17780) 4294614..4294862 - 249 WP_000844758.1 ribbon-helix-helix domain-containing protein Antitoxin
FH593_RS17785 (FH593_17785) 4295677..4295973 - 297 WP_000477061.1 helix-turn-helix transcriptional regulator -
FH593_RS17790 (FH593_17790) 4296127..4296585 + 459 WP_000453267.1 hypothetical protein -
FH593_RS17795 (FH593_17795) 4297227..4299209 - 1983 WP_000802799.1 HD family phosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12371.30 Da        Isoelectric Point: 9.7995

>T235747 WP_000617908.1 NZ_CP092161:c4294627-4294286 [Leptospira interrogans]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGKVEIGLKLVTGLD

Download         Length: 342 bp

>T235747 NZ_LR134340:c2332284-2332129 [Escherichia marmotae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT235747 WP_000844758.1 NZ_CP092161:c4294862-4294614 [Leptospira interrogans]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235747 NZ_LR134340:2332296-2332354 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HD92

References