235741

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 28599..29170 Replicon plasmid pLiSL7
Accession NZ_CP092154
Organism Leptospira interrogans strain FMAS_AP7

Toxin (Protein)


Gene name mazF Uniprot ID Q8F5A3
Locus tag FH595_RS19070 Protein ID WP_000240418.1
Coordinates 28599..28940 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M6U553
Locus tag FH595_RS19075 Protein ID WP_000443825.1
Coordinates 28934..29170 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH595_RS19040 (FH595_19040) 24421..25032 - 612 WP_000851075.1 hypothetical protein -
FH595_RS19045 (FH595_19045) 26128..26328 - 201 WP_001206464.1 hypothetical protein -
FH595_RS19050 (FH595_19050) 26752..27477 + 726 WP_239033801.1 hypothetical protein -
FH595_RS19055 (FH595_19055) 27480..27821 + 342 WP_000727287.1 hypothetical protein -
FH595_RS19060 (FH595_19060) 27882..28148 + 267 WP_000844450.1 hypothetical protein -
FH595_RS19065 (FH595_19065) 28148..28531 + 384 WP_000617796.1 hypothetical protein -
FH595_RS19070 (FH595_19070) 28599..28940 - 342 WP_000240418.1 endoribonuclease MazF Toxin
FH595_RS19075 (FH595_19075) 28934..29170 - 237 WP_000443825.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FH595_RS19080 (FH595_19080) 29519..30310 - 792 WP_061243661.1 hypothetical protein -
FH595_RS19085 (FH595_19085) 30804..31049 + 246 WP_061226370.1 hypothetical protein -
FH595_RS19090 (FH595_19090) 31192..32331 + 1140 WP_239043563.1 leucine-rich repeat domain-containing protein -
FH595_RS19095 (FH595_19095) 32603..33541 + 939 WP_061234895.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..100329 100329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.12 Da        Isoelectric Point: 9.9595

>T235741 WP_000240418.1 NZ_CP092154:c28940-28599 [Leptospira interrogans]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF

Download         Length: 342 bp

>T235741 NZ_LR134340:378895-379068 [Escherichia marmotae]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTCTCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGCCTGCCCGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8728.95 Da        Isoelectric Point: 5.6663

>AT235741 WP_000443825.1 NZ_CP092154:c29170-28934 [Leptospira interrogans]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 237 bp

>AT235741 NZ_LR134340:378572-378868 [Escherichia marmotae]
ATGGAAGGTATAAACAGGTTCAAAACTTACGTTGTTTCTTTTGATTATCCATCATCTTATTACTCAGTTTTCTTAAGGTT
AAGGTCGTTAATGTATGATATGGATTTCTCCTCTATAGTTGCTGATGAATATGGAATACCACGACAATTGAATGAGAATG
CTTTCGCAATAACGACATCATTAGCCGCAAGTGAAATTGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCAGATATT
GATTTTGACCTCAACATTATGATAGTCGATGACTATTTCCGTCAGTTCTACAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D8SL30

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HC33

References