235738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 2001886..2002462 Replicon chromosome
Accession NZ_CP092151
Organism Leptospira interrogans strain FMAS_PN2

Toxin (Protein)


Gene name chpK Uniprot ID A0A8I0U3W7
Locus tag FH597_RS09820 Protein ID WP_000617905.1
Coordinates 2002121..2002462 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID A0A8I0U107
Locus tag FH597_RS09815 Protein ID WP_000844756.1
Coordinates 2001886..2002134 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH597_RS09805 (FH597_09820) 1999025..1999484 - 460 Protein_1592 hypothetical protein -
FH597_RS09810 (FH597_09825) 1999638..1999934 + 297 WP_061234463.1 helix-turn-helix transcriptional regulator -
FH597_RS09815 (FH597_09830) 2001886..2002134 + 249 WP_000844756.1 ribbon-helix-helix domain-containing protein Antitoxin
FH597_RS09820 (FH597_09835) 2002121..2002462 + 342 WP_000617905.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FH597_RS09825 (FH597_09840) 2003486..2004478 - 993 WP_000041092.1 aldolase/citrate lyase family protein -
FH597_RS09830 (FH597_09845) 2004618..2005553 - 936 WP_000004531.1 ornithine carbamoyltransferase -
FH597_RS09835 (FH597_09850) 2006357..2006824 + 468 WP_000060052.1 hypothetical protein -
FH597_RS09840 (FH597_09855) 2006821..2007225 + 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12212.13 Da        Isoelectric Point: 5.0939

>T235738 WP_000617905.1 NZ_CP092151:2002121-2002462 [Leptospira interrogans]
MIRGEIWLVDLGIPFGSEPGFKCPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T235738 NZ_LR134337:465941-466282 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCAGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9324.75 Da        Isoelectric Point: 10.3019

>AT235738 WP_000844756.1 NZ_CP092151:2001886-2002134 [Leptospira interrogans]
MKTAISIPDELFKAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETKNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235738 NZ_LR134337:465711-465941 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References