Detailed information of TA system TA235733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4687835..4688348
• Replicon: chromosome
• Accession: NZ_CP092121
• Organism: Klebsiella quasipneumoniae subsp. similipneumoniae strain IF3SW-P1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MEO32_RS22610
• Protein ID: WP_064190102.1
• Coordinates: 4687835..4688116 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MEO32_RS22615
• Protein ID: WP_002886901.1
• Coordinates: 4688106..4688348 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MEO32_RS22595 (4682877)	4682877..4684532	+	1656	WP_064178460.1	alpha,alpha-phosphotrehalase	-
MEO32_RS22600 (4684918)	4684918..4687056	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
MEO32_RS22605 (4687367)	4687367..4687831	+	465	WP_064190101.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MEO32_RS22610 (4687835)	4687835..4688116	-	282	WP_064190102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MEO32_RS22615 (4688106)	4688106..4688348	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MEO32_RS22620 (4688426)	4688426..4690336	-	1911	WP_057212387.1	PRD domain-containing protein	-
MEO32_RS22625 (4690359)	4690359..4691510	-	1152	WP_065878155.1	lactonase family protein	-
MEO32_RS22630 (4691577)	4691577..4692317	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11031.81 Da
• Isoelectric Point: 10.1752

>T235733 WP_064190102.1 NZ_CP092121:c4688116-4687835 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T235733 NZ_LR134335:3532713-3533138 [Yersinia enterocolitica subsp. palearctica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT235733 WP_002886901.1 NZ_CP092121:c4688348-4688106 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT235733 NZ_LR134335:3532466-3532732 [Yersinia enterocolitica subsp. palearctica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0