Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3964806..3965425 Replicon chromosome
Accession NZ_CP092121
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain IF3SW-P1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MEO32_RS19215 Protein ID WP_002892050.1
Coordinates 3965207..3965425 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MEO32_RS19210 Protein ID WP_002892066.1
Coordinates 3964806..3965180 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MEO32_RS19200 (3959959) 3959959..3961152 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MEO32_RS19205 (3961175) 3961175..3964321 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
MEO32_RS19210 (3964806) 3964806..3965180 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MEO32_RS19215 (3965207) 3965207..3965425 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MEO32_RS19220 (3965583) 3965583..3966149 + 567 WP_004204750.1 maltose O-acetyltransferase -
MEO32_RS19225 (3966121) 3966121..3966243 - 123 WP_032426076.1 hypothetical protein -
MEO32_RS19230 (3966286) 3966286..3966756 + 471 WP_004204751.1 YlaC family protein -
MEO32_RS19235 (3966725) 3966725..3968182 - 1458 WP_065903537.1 PLP-dependent aminotransferase family protein -
MEO32_RS19240 (3968283) 3968283..3968981 + 699 WP_064187826.1 GNAT family protein -
MEO32_RS19245 (3968978) 3968978..3969118 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MEO32_RS19250 (3969118) 3969118..3969381 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T235731 WP_002892050.1 NZ_CP092121:3965207-3965425 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T235731 NZ_LR134335:3187532-3187819 [Yersinia enterocolitica subsp. palearctica]
ATGATTTATAAAGTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT235731 WP_002892066.1 NZ_CP092121:3964806-3965180 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT235731 NZ_LR134335:3187284-3187535 [Yersinia enterocolitica subsp. palearctica]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References