Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 738330..738943 Replicon chromosome
Accession NZ_CP092112
Organism Leptospira noguchii strain IP1804061

Toxin (Protein)


Gene name hicA Uniprot ID T0FDD9
Locus tag MAL06_RS03175 Protein ID WP_002178286.1
Coordinates 738683..738943 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MAL06_RS03170 Protein ID WP_141598270.1
Coordinates 738330..738686 (-) Length 119 a.a.

Genomic Context

MAL06_RS21285MAL06_RS03200MAL06_RS03205MAL06_RS03140MAL06_RS03145MAL06_RS03150MAL06_RS03155MAL06_RS03160MAL06_RS03165MAL06_RS03170MAL06_RS03175MAL06_RS03180MAL06_RS03185MAL06_RS03190MAL06_RS03195
Location: 741545..741667 (123 bp)
Type: Others
Protein ID: WP_016559266.1
Location: 742251..742508 (258 bp)
Type: Others
Protein ID: Protein_645
Location: 742780..743712 (933 bp)
Type: Others
Protein ID: WP_243820436.1
Location: 735712..736053 (342 bp)
Type: Others
Protein ID: WP_002155521.1
Location: 736040..736288 (249 bp)
Type: Others
Protein ID: WP_004425715.1
Location: 736542..736814 (273 bp)
Type: Others
Protein ID: WP_135686010.1
Location: 736801..737100 (300 bp)
Type: Others
Protein ID: WP_141598267.1
Location: 737425..737826 (402 bp)
Type: Others
Protein ID: WP_141598268.1
Location: 737826..738056 (231 bp)
Type: Others
Protein ID: WP_002998826.1
Location: 738330..738686 (357 bp)
Type: Antitoxin
Protein ID: WP_141598270.1
Location: 738683..738943 (261 bp)
Type: Toxin
Protein ID: WP_002178286.1
Location: 739209..739598 (390 bp)
Type: Others
Protein ID: WP_141598271.1
Location: 739595..739906 (312 bp)
Type: Others
Protein ID: WP_141598272.1
Location: 740200..741204 (1005 bp)
Type: Others
Protein ID: WP_141598273.1
Location: 741679..742092 (414 bp)
Type: Others
Protein ID: WP_141598587.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL06_RS03140 (MAL06_03140)735712..736053-342WP_002155521.1type II toxin-antitoxin system PemK/MazF family toxin-
MAL06_RS03145 (MAL06_03145)736040..736288-249WP_004425715.1ribbon-helix-helix domain-containing protein-
MAL06_RS03150 (MAL06_03150)736542..736814-273WP_135686010.1BrnA antitoxin family protein-
MAL06_RS03155 (MAL06_03155)736801..737100-300WP_141598267.1BrnT family toxin-
MAL06_RS03160 (MAL06_03160)737425..737826-402WP_141598268.1type II toxin-antitoxin system VapC family toxin-
MAL06_RS03165 (MAL06_03165)737826..738056-231WP_002998826.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
MAL06_RS03170 (MAL06_03170)738330..738686-357WP_141598270.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
MAL06_RS03175 (MAL06_03175)738683..738943-261WP_002178286.1type II toxin-antitoxin system HicA family toxinToxin
MAL06_RS03180 (MAL06_03180)739209..739598-390WP_141598271.1type II toxin-antitoxin system MqsA family antitoxin-
MAL06_RS03185 (MAL06_03185)739595..739906-312WP_141598272.1type II toxin-antitoxin system MqsR family toxin-
MAL06_RS03190 (MAL06_03190)740200..741204-1005WP_141598273.1DUF2971 domain-containing protein-
MAL06_RS21285741545..741667+123WP_016559266.1hypothetical protein-
MAL06_RS03195 (MAL06_03195)741679..742092-414WP_141598587.1helix-turn-helix transcriptional regulator-
MAL06_RS03200 (MAL06_03200)742251..742508+258Protein_645helix-turn-helix transcriptional regulator-
MAL06_RS03205 (MAL06_03205)742780..743712+933WP_243820436.1patatin-like phospholipase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10032.49 Da        Isoelectric Point: 10.2818

>T235720 WP_002178286.1 NZ_CP092112:c738943-738683 [Leptospira noguchii]
VSKSEKLIQRFLGRPKDFSYDELRKLFSGFGYIEDNSGKSSGSRVAWIHSETKHIIRLHKPHPKNILKSYQINQILDELK
SEGYIK

Download         Length: 261 bp

>T235720 NZ_LR134334:c6577576-6577286 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13610.59 Da        Isoelectric Point: 7.2781

>AT235720 WP_141598270.1 NZ_CP092112:c738686-738330 [Leptospira noguchii]
MKDIIEYNGFLGSVHFDADDEVFFGKIEGIEDLVSFEGESVKQLKKAFQESVDDYLILCKKAKKSPEKSFKGSFNVRIPT
ELHRRVYRKSLREGISLNQLVQRALEKEITELKTPHFG

Download         Length: 357 bp

>AT235720 NZ_LR134334:c6577871-6577578 [Pseudomonas chlororaphis]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBT0FDD9

Antitoxin

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Source
ID
Structure
No matching records found

References