Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA(toxin) |
| Location | 738330..738943 | Replicon | chromosome |
| Accession | NZ_CP092112 | ||
| Organism | Leptospira noguchii strain IP1804061 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | T0FDD9 |
| Locus tag | MAL06_RS03175 | Protein ID | WP_002178286.1 |
| Coordinates | 738683..738943 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | MAL06_RS03170 | Protein ID | WP_141598270.1 |
| Coordinates | 738330..738686 (-) | Length | 119 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAL06_RS03140 (MAL06_03140) | 735712..736053 | - | 342 | WP_002155521.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| MAL06_RS03145 (MAL06_03145) | 736040..736288 | - | 249 | WP_004425715.1 | ribbon-helix-helix domain-containing protein | - |
| MAL06_RS03150 (MAL06_03150) | 736542..736814 | - | 273 | WP_135686010.1 | BrnA antitoxin family protein | - |
| MAL06_RS03155 (MAL06_03155) | 736801..737100 | - | 300 | WP_141598267.1 | BrnT family toxin | - |
| MAL06_RS03160 (MAL06_03160) | 737425..737826 | - | 402 | WP_141598268.1 | type II toxin-antitoxin system VapC family toxin | - |
| MAL06_RS03165 (MAL06_03165) | 737826..738056 | - | 231 | WP_002998826.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| MAL06_RS03170 (MAL06_03170) | 738330..738686 | - | 357 | WP_141598270.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MAL06_RS03175 (MAL06_03175) | 738683..738943 | - | 261 | WP_002178286.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MAL06_RS03180 (MAL06_03180) | 739209..739598 | - | 390 | WP_141598271.1 | type II toxin-antitoxin system MqsA family antitoxin | - |
| MAL06_RS03185 (MAL06_03185) | 739595..739906 | - | 312 | WP_141598272.1 | type II toxin-antitoxin system MqsR family toxin | - |
| MAL06_RS03190 (MAL06_03190) | 740200..741204 | - | 1005 | WP_141598273.1 | DUF2971 domain-containing protein | - |
| MAL06_RS21285 | 741545..741667 | + | 123 | WP_016559266.1 | hypothetical protein | - |
| MAL06_RS03195 (MAL06_03195) | 741679..742092 | - | 414 | WP_141598587.1 | helix-turn-helix transcriptional regulator | - |
| MAL06_RS03200 (MAL06_03200) | 742251..742508 | + | 258 | Protein_645 | helix-turn-helix transcriptional regulator | - |
| MAL06_RS03205 (MAL06_03205) | 742780..743712 | + | 933 | WP_243820436.1 | patatin-like phospholipase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10032.49 Da Isoelectric Point: 10.2818
>T235720 WP_002178286.1 NZ_CP092112:c738943-738683 [Leptospira noguchii]
VSKSEKLIQRFLGRPKDFSYDELRKLFSGFGYIEDNSGKSSGSRVAWIHSETKHIIRLHKPHPKNILKSYQINQILDELK
SEGYIK
VSKSEKLIQRFLGRPKDFSYDELRKLFSGFGYIEDNSGKSSGSRVAWIHSETKHIIRLHKPHPKNILKSYQINQILDELK
SEGYIK
Download Length: 261 bp
>T235720 NZ_LR134334:c6577576-6577286 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 13610.59 Da Isoelectric Point: 7.2781
>AT235720 WP_141598270.1 NZ_CP092112:c738686-738330 [Leptospira noguchii]
MKDIIEYNGFLGSVHFDADDEVFFGKIEGIEDLVSFEGESVKQLKKAFQESVDDYLILCKKAKKSPEKSFKGSFNVRIPT
ELHRRVYRKSLREGISLNQLVQRALEKEITELKTPHFG
MKDIIEYNGFLGSVHFDADDEVFFGKIEGIEDLVSFEGESVKQLKKAFQESVDDYLILCKKAKKSPEKSFKGSFNVRIPT
ELHRRVYRKSLREGISLNQLVQRALEKEITELKTPHFG
Download Length: 357 bp
>AT235720 NZ_LR134334:c6577871-6577578 [Pseudomonas chlororaphis]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|