Detailed information of TA system TA023572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 464428..464930
• Replicon: chromosome
• Accession: NC_012115
• Organism: Nautilia profundicola AmH

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B9L8I4
• Locus tag: NAMH_RS02605
• Protein ID: WP_015901754.1
• Coordinates: 464673..464930 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B9L8I3
• Locus tag: NAMH_RS02600
• Protein ID: WP_015902045.1
• Coordinates: 464428..464673 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NAMH_RS02575	459472..460140	+	669	WP_015902608.1	ATP-binding cassette domain-containing protein	-
NAMH_RS02580	460127..460912	+	786	WP_012663820.1	hypothetical protein	-
NAMH_RS02585	460909..462027	+	1119	WP_015902529.1	peptidoglycan DD-metalloendopeptidase family protein	-
NAMH_RS02590	462337..463662	+	1326	WP_015902786.1	transcription termination factor Rho	-
NAMH_RS02595	463655..464392	+	738	WP_012663797.1	glutamate racemase	-
NAMH_RS02600	464428..464673	+	246	WP_015902045.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
NAMH_RS02605	464673..464930	+	258	WP_015901754.1	Txe/YoeB family addiction module toxin	Toxin
NAMH_RS02610	464921..465196	-	276	WP_015902511.1	plasmid stabilization protein	-
NAMH_RS09120	465189..465451	-	263	Protein_502	type II toxin-antitoxin system Phd/YefM family antitoxin	-
NAMH_RS02620	465496..466131	-	636	WP_015901918.1	SDR family NAD(P)-dependent oxidoreductase	-
NAMH_RS02625	466422..467339	-	918	WP_015902104.1	radical SAM protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10351.06 Da
• Isoelectric Point: 7.8681

>T23572 WP_015901754.1 NC_012115:464673-464930 [Nautilia profundicola AmH]
MKIAFTPEGWEDYLYWQKIDKKIVKKINELIKDIKRHPFEGLGKPEALKFDFAGCYSRRINQEHRLIYMIDEDEVIIIAC
RYHYQ

Nucleotide

• Length: 258 bp

>T23572 NC_012115:464673-464930 [Nautilia profundicola AmH]
ATGAAAATAGCTTTTACACCTGAAGGTTGGGAAGATTATTTATATTGGCAGAAAATTGATAAAAAAATTGTAAAAAAAAT
AAACGAACTGATTAAAGACATTAAAAGACATCCGTTTGAAGGTTTAGGCAAACCTGAAGCATTGAAGTTTGATTTTGCAG
GATGTTATTCAAGAAGAATAAATCAAGAACACAGACTGATATATATGATTGATGAAGACGAAGTTATAATAATCGCATGC
AGATATCATTACCAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9637.13 Da
• Isoelectric Point: 9.4262

>AT23572 WP_015902045.1 NC_012115:464428-464673 [Nautilia profundicola AmH]
MEVVTMSEARNNLKEIFEKVYFNHDEVIIHRKGKESVVMISLDEFNSLKETEYLMKNQANREWIKKSINNAKSGKKIYKE
I

Nucleotide

• Length: 246 bp

>AT23572 NC_012115:464428-464673 [Nautilia profundicola AmH]
ATGGAAGTAGTAACAATGAGTGAAGCCAGAAATAACCTTAAAGAAATTTTTGAAAAAGTTTATTTTAATCATGATGAAGT
AATTATACACAGAAAAGGAAAAGAAAGTGTTGTGATGATTTCTCTTGATGAATTCAACTCTTTAAAAGAAACCGAATATT
TAATGAAAAACCAGGCAAACAGAGAGTGGATTAAAAAATCCATAAACAATGCGAAATCAGGTAAAAAAATCTATAAAGAA
ATATAA

Structures

Toxin

• AlphaFold DB: B9L8I4

Antitoxin

• AlphaFold DB: B9L8I3