Detailed information of TA system TA235719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 737425..738056
• Replicon: chromosome
• Accession: NZ_CP092112
• Organism: Leptospira noguchii strain IP1804061

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MAL06_RS03160
• Protein ID: WP_141598268.1
• Coordinates: 737425..737826 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: N1WMP3
• Locus tag: MAL06_RS03165
• Protein ID: WP_002998826.1
• Coordinates: 737826..738056 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAL06_RS03140 (MAL06_03140)	735712..736053	-	342	WP_002155521.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MAL06_RS03145 (MAL06_03145)	736040..736288	-	249	WP_004425715.1	ribbon-helix-helix domain-containing protein	-
MAL06_RS03150 (MAL06_03150)	736542..736814	-	273	WP_135686010.1	BrnA antitoxin family protein	-
MAL06_RS03155 (MAL06_03155)	736801..737100	-	300	WP_141598267.1	BrnT family toxin	-
MAL06_RS03160 (MAL06_03160)	737425..737826	-	402	WP_141598268.1	type II toxin-antitoxin system VapC family toxin	Toxin
MAL06_RS03165 (MAL06_03165)	737826..738056	-	231	WP_002998826.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MAL06_RS03170 (MAL06_03170)	738330..738686	-	357	WP_141598270.1	type II toxin-antitoxin system HicB family antitoxin	-
MAL06_RS03175 (MAL06_03175)	738683..738943	-	261	WP_002178286.1	type II toxin-antitoxin system HicA family toxin	-
MAL06_RS03180 (MAL06_03180)	739209..739598	-	390	WP_141598271.1	type II toxin-antitoxin system MqsA family antitoxin	-
MAL06_RS03185 (MAL06_03185)	739595..739906	-	312	WP_141598272.1	type II toxin-antitoxin system MqsR family toxin	-
MAL06_RS03190 (MAL06_03190)	740200..741204	-	1005	WP_141598273.1	DUF2971 domain-containing protein	-
MAL06_RS21285	741545..741667	+	123	WP_016559266.1	hypothetical protein	-
MAL06_RS03195 (MAL06_03195)	741679..742092	-	414	WP_141598587.1	helix-turn-helix transcriptional regulator	-
MAL06_RS03200 (MAL06_03200)	742251..742508	+	258	Protein_645	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15214.82 Da
• Isoelectric Point: 9.4565

>T235719 WP_141598268.1 NZ_CP092112:c737826-737425 [Leptospira noguchii]
MYLLDTNICIFLIKKKNTALLENLKKKLNKGLFVSSLTVAELEFGIQKSEFKEKNKISLIEFLSIFNIISFTDKDAESYG
IIRAELEKRGNVIGSIDMLLAAQAISNNFIFVTNNTKEFKRIKELKLEDWTAS

Nucleotide

• Length: 402 bp

>T235719 NZ_LR134334:c6563234-6563052 [Pseudomonas chlororaphis]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGTAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAAGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8585.80 Da
• Isoelectric Point: 8.6850

>AT235719 WP_002998826.1 NZ_CP092112:c738056-737826 [Leptospira noguchii]
MQTAKLFTNGRSQAVRLPKEFQFSGDDVLIQKVGEAVILVPKNKAWNVFLDGLNGFSDDFMEAGREQPKSDKREKL

Nucleotide

• Length: 231 bp

>AT235719 NZ_LR134334:c6563016-6562615 [Pseudomonas chlororaphis]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCGGGCGCGGT
AACCGCCGGCGACACCTTCGAGGCCGCGTATAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAGCTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACGCACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAGAAGGTCAATGTGACCCTGCCGGGTTACGTGATTCAACGAAT
CGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGATCGTCATTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Structures

Antitoxin

• AlphaFold DB: N1WMP3