Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1183325..1183833 Replicon chromosome
Accession NZ_CP092106
Organism Vibrio sp. JC009

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L3Q72_RS05540 Protein ID WP_275131658.1
Coordinates 1183325..1183585 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag L3Q72_RS05545 Protein ID WP_275131659.1
Coordinates 1183582..1183833 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q72_RS05505 (L3Q72_05500) 1178905..1179219 - 315 WP_275131652.1 cupin domain-containing protein -
L3Q72_RS05510 (L3Q72_05505) 1179396..1179677 + 282 WP_275131653.1 helix-turn-helix transcriptional regulator -
L3Q72_RS05515 (L3Q72_05510) 1179894..1180469 + 576 WP_275131654.1 outer membrane beta-barrel protein -
L3Q72_RS05520 (L3Q72_05515) 1180647..1180727 + 81 Protein_1049 CopG family transcriptional regulator -
L3Q72_RS05525 (L3Q72_05520) 1180842..1181093 - 252 WP_275131655.1 DUF2999 family protein -
L3Q72_RS05530 (L3Q72_05525) 1181250..1182578 - 1329 WP_275131656.1 guanine deaminase -
L3Q72_RS05535 (L3Q72_05530) 1182895..1183275 + 381 WP_275131657.1 CoA-binding protein -
L3Q72_RS05540 (L3Q72_05535) 1183325..1183585 - 261 WP_275131658.1 Txe/YoeB family addiction module toxin Toxin
L3Q72_RS05545 (L3Q72_05540) 1183582..1183833 - 252 WP_275131659.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L3Q72_RS05550 (L3Q72_05545) 1184027..1186342 - 2316 WP_275131660.1 methyl-accepting chemotaxis protein -
L3Q72_RS05555 (L3Q72_05550) 1186566..1188479 - 1914 WP_275131661.1 TRAP transporter permease -
L3Q72_RS05560 1188478..1188609 + 132 WP_275131662.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10548.22 Da        Isoelectric Point: 9.9315

>T235705 WP_275131658.1 NZ_CP092106:c1183585-1183325 [Vibrio sp. JC009]
MKLTFSAHAWEDYLYWQKTDKKILKRINTLIKDIRREPYEGLGKPEPLKHGLSGYWSRRINDEHRIIYKCKENNILIAQL
RYHYEL

Download         Length: 261 bp

>T235705 NZ_LR134331:c522867-522682 [Lacticaseibacillus rhamnosus]
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9167.43 Da        Isoelectric Point: 4.4621

>AT235705 WP_275131659.1 NZ_CP092106:c1183833-1183582 [Vibrio sp. JC009]
MDAISYTAARANLASTMKKVCNDHAPVIITRKSEAPVVMISLEDFEAMQETTYLLRAPANARRLLESVAELESGNGEERD
LIE

Download         Length: 252 bp

>AT235705 NZ_LR134331:c523167-522895 [Lacticaseibacillus rhamnosus]
ATGACCAAAAAATCCCGCATCAGCGTTAGGATTGATACCAAAACTAAAGAACGAGCGCTCCATGTTCTTAATAGCATGGG
ATTAGATATTTCCTCGGCTATTAACATGTACCTGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACCTCCAATGT
CATTTGTTGATCAGCTTCAAGTTGCAGAAGCTGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTCGATGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References