Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 215721..217501 Replicon chromosome
Accession NZ_CP092106
Organism Vibrio sp. JC009

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag L3Q72_RS01030 Protein ID WP_275130853.1
Coordinates 215721..217070 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag L3Q72_RS01035 Protein ID WP_275130854.1
Coordinates 217067..217501 (+) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q72_RS01000 (L3Q72_01000) 211014..212243 + 1230 WP_275130848.1 MBL fold metallo-hydrolase -
L3Q72_RS01005 (L3Q72_01005) 212400..212750 - 351 WP_275130849.1 hypothetical protein -
L3Q72_RS01010 (L3Q72_01010) 212954..214450 + 1497 WP_275130850.1 IS21 family transposase -
L3Q72_RS01015 (L3Q72_01015) 214440..215198 + 759 WP_275130851.1 IS21-like element helper ATPase IstB -
L3Q72_RS01020 (L3Q72_01020) 215198..215374 + 177 WP_275130852.1 hypothetical protein -
L3Q72_RS01025 (L3Q72_01025) 215451..215603 + 153 Protein_193 MBL fold metallo-hydrolase RNA specificity domain-containing protein -
L3Q72_RS01030 (L3Q72_01030) 215721..217070 + 1350 WP_275130853.1 HipA domain-containing protein Toxin
L3Q72_RS01035 (L3Q72_01035) 217067..217501 + 435 WP_275130854.1 helix-turn-helix domain-containing protein Antitoxin
L3Q72_RS01040 (L3Q72_01040) 218068..219282 - 1215 WP_275130855.1 hypothetical protein -
L3Q72_RS01045 (L3Q72_01045) 219406..220008 - 603 WP_275130856.1 hypothetical protein -
L3Q72_RS01050 (L3Q72_01050) 220293..221459 - 1167 WP_275130857.1 nucleotide sugar dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - wbtL / manB / ugd 173637..233325 59688


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(73-126)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 50947.76 Da        Isoelectric Point: 4.6807

>T235701 WP_275130853.1 NZ_CP092106:215721-217070 [Vibrio sp. JC009]
MKHLTLQAFLEMQWVDIATIGFPNSEQNSYQLTILDYESGYALEFLERDDNHAVSLNYPVSLFFDDKGKPGWLKFLDDIV
PSGASRRYWINYLDLEGLTVDQQNYVLLKHGTISPVGNLRVKESLPEFNPLAESLFFSIDDVKNRASDFLDYAQLRGATA
GGATGAGGEAPKLLLRCSAKEQIWIDTYQNNLANQDIHYLVKYPRGSRLEVDCNILRAEYYYYHELAALGFDTIPIENMR
LEEGVNYPSLWLPRFDVSFSEEGQVKRYSMESVYSMLDKSPGVTLDHESVIREVIQKITSSHMVIAQGFHFDVKAFVVEW
VRRDLLNIIFGNSDNHGRNTSFIKDEGSIRLAPVYDFAPMKADPEGIPRTTKWGQQFEVGGEYNFPGIADSLADLIPAEE
LLTALKASAKQLLDLKARLEQRGVPEQIITMPAIGFDYIPEKLTRWGLL

Download         Length: 1350 bp

>T235701 NZ_LR134330:3437397-3438266 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16210.69 Da        Isoelectric Point: 10.5918

>AT235701 WP_275130854.1 NZ_CP092106:217067-217501 [Vibrio sp. JC009]
MKNQSADETIRKIKAKQQASNVSAVNEKEVTYTVNPQSRQRASKDTVPMDAQRRKIAMDRIIKKVLLGEITQGQALKALR
VEVLGLRQDSFAEIVSVSRKTLSEVENDKGNYTSEIINKLFKPFGLQMGLVPTSRHRLLDLLSD

Download         Length: 435 bp

>AT235701 NZ_LR134330:3438259-3439092 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCATCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References