Detailed information of TA system TA023570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 4977264..4978063
• Replicon: chromosome
• Accession: NC_012108
• Organism: Desulfobacterium autotrophicum HRM2

Toxin (Protein)

• Gene name: -
• Uniprot ID: C0QEY0
• Locus tag: HRM2_RS21825
• Protein ID: WP_015906209.1
• Coordinates: 4977264..4977797 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: C0QEY1
• Locus tag: HRM2_RS21830
• Protein ID: WP_015906210.1
• Coordinates: 4977794..4978063 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRM2_RS21800	4973311..4973595	+	285	WP_041274234.1	hypothetical protein	-
HRM2_RS21805	4973733..4975175	+	1443	WP_083776635.1	trimethylamine methyltransferase family protein	-
HRM2_RS21810	4975217..4975501	-	285	WP_083776636.1	DUF1214 domain-containing protein	-
HRM2_RS21815	4975920..4976309	-	390	WP_015906207.1	DUF1254 domain-containing protein	-
HRM2_RS21820	4976506..4977159	-	654	WP_015906208.1	HAD family hydrolase	-
HRM2_RS21825	4977264..4977797	-	534	WP_015906209.1	GNAT family N-acetyltransferase	Toxin
HRM2_RS21830	4977794..4978063	-	270	WP_015906210.1	DUF1778 domain-containing protein	Antitoxin
HRM2_RS21835	4978722..4980380	-	1659	WP_187149299.1	IS1634 family transposase	-
HRM2_RS21840	4980565..4981104	+	540	WP_015906211.1	DDE-type integrase/transposase/recombinase	-
HRM2_RS21845	4981288..4981800	+	513	WP_015906212.1	hypothetical protein	-
HRM2_RS21850	4981769..4982014	+	246	Protein_4269	hypothetical protein	-
HRM2_RS21855	4982209..4982607	+	399	WP_012663014.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4975920..5030710	54790

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-79)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20121.76 Da
• Isoelectric Point: 9.1090

>T23570 WP_015906209.1 NC_012108:c4977797-4977264 [Desulfobacterium autotrophicum HRM2]
MSWAKEFIELDKAIHDRASFDCGEVELNEFIRTKAAKHMIAGISRTMLLPASVPLPNGKYPICTFYTIAPSSISRGTLPK
KLMKKLPRYPVPVFLLAQLAVHSEYHGQGLGKITLIKALEYLWEINSHMRAYAIIVDCINEAAENFYSKYGFEVLCCQNS
KVRMFMPMKIVGQLFQQ

Nucleotide

• Length: 534 bp

>T23570 NC_012108:c4977797-4977264 [Desulfobacterium autotrophicum HRM2]
ATGAGTTGGGCTAAAGAATTCATAGAGCTTGACAAGGCTATCCACGATCGGGCTTCATTTGATTGCGGTGAAGTTGAATT
AAATGAATTCATCCGAACTAAGGCTGCAAAGCATATGATCGCAGGCATAAGCAGAACAATGCTATTGCCCGCCTCCGTTC
CACTTCCTAACGGTAAATACCCCATTTGTACCTTTTATACAATTGCACCTAGTTCTATTAGCAGAGGAACTTTACCAAAA
AAACTTATGAAAAAGTTGCCACGTTATCCTGTGCCAGTATTTTTACTTGCTCAGTTAGCTGTTCATTCAGAATATCATGG
TCAAGGTTTGGGGAAAATCACCCTAATAAAAGCACTTGAATATTTATGGGAAATAAATTCTCACATGAGAGCCTATGCAA
TTATCGTCGATTGCATAAATGAAGCTGCTGAGAATTTTTATTCAAAATACGGTTTTGAAGTATTGTGCTGCCAAAATAGT
AAGGTACGAATGTTCATGCCAATGAAAATTGTAGGGCAATTATTTCAACAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9934.59 Da
• Isoelectric Point: 8.0052

>AT23570 WP_015906210.1 NC_012108:c4978063-4977794 [Desulfobacterium autotrophicum HRM2]
MATTRLDMRLDQEIKAKAEKASALLGLKSLTEYIVKLIDENATQVIAQHESIIVENDIFDLFISACEKTQKPNKALLDAK
SFAKKQGIK

Nucleotide

• Length: 270 bp

>AT23570 NC_012108:c4978063-4977794 [Desulfobacterium autotrophicum HRM2]
ATGGCTACCACTCGCCTTGACATGAGATTAGATCAAGAGATTAAAGCAAAAGCTGAAAAAGCGTCGGCCTTGCTTGGATT
AAAAAGTCTTACTGAATATATTGTCAAACTAATTGATGAAAACGCAACCCAGGTGATTGCTCAACATGAAAGTATCATCG
TTGAAAATGATATTTTTGATCTTTTTATTAGTGCTTGTGAAAAAACTCAAAAACCAAATAAAGCTCTGCTGGATGCGAAA
TCTTTTGCCAAAAAGCAAGGGATCAAATGA

Structures

Toxin

• AlphaFold DB: C0QEY0

Antitoxin

• AlphaFold DB: C0QEY1