Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 103062..103597 Replicon plasmid pLP337
Accession NZ_CP092103
Organism Rhodococcus qingshengii strain F2-2

Toxin (Protein)


Gene name mazF Uniprot ID A0A937CJQ5
Locus tag JKI97_RS31545 Protein ID WP_019749527.1
Coordinates 103062..103361 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JKI97_RS31550 Protein ID WP_151097285.1
Coordinates 103361..103597 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKI97_RS31530 (JKI97_31520) 100105..100212 - 108 Protein_100 ArsR family transcriptional regulator -
JKI97_RS31535 (JKI97_31525) 100386..101183 - 798 WP_151097000.1 hypothetical protein -
JKI97_RS31540 (JKI97_31530) 101183..103033 - 1851 WP_151097283.1 hypothetical protein -
JKI97_RS31545 (JKI97_31535) 103062..103361 - 300 WP_019749527.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JKI97_RS31550 (JKI97_31540) 103361..103597 - 237 WP_151097285.1 YlcI/YnfO family protein Antitoxin
JKI97_RS31555 (JKI97_31545) 104027..104653 - 627 WP_241064931.1 TetR/AcrR family transcriptional regulator -
JKI97_RS31560 (JKI97_31550) 104763..105737 - 975 WP_151097289.1 DUF2637 domain-containing protein -
JKI97_RS31565 (JKI97_31555) 106155..107402 - 1248 WP_030538129.1 IS256 family transposase -
JKI97_RS31570 (JKI97_31560) 107791..107943 - 153 WP_007733689.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..337428 337428
- flank IS/Tn - - 106155..107402 1247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10414.98 Da        Isoelectric Point: 4.6942

>T235697 WP_019749527.1 NZ_CP092103:c103361-103062 [Rhodococcus qingshengii]
MRPIHEANLDSVRPVLVLTREMVRPHLGTVTVAPITGEIRGLSTEVSVSAANGLSADAVVSCDHITTIPVSALGNIIGYL
LPAQEESLSIAVRAAFDLE

Download         Length: 300 bp

>T235697 NZ_LR134329:4001963-4002274 [Bordetella parapertussis]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAACTGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8757.81 Da        Isoelectric Point: 6.7266

>AT235697 WP_151097285.1 NZ_CP092103:c103597-103361 [Rhodococcus qingshengii]
MSTQIAVRLPDEIVEFLDDEVREHRAASRASLVLRALERERRRQIAARDAEILSAATSEHDLSPLAHRAVNRQPTGST

Download         Length: 237 bp

>AT235697 NZ_LR134329:4002277-4002576 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References