Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4628849..4629365 Replicon chromosome
Accession NZ_CP092077
Organism Klebsiella pneumoniae strain P1-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag MDE60_RS22460 Protein ID WP_009486548.1
Coordinates 4628849..4629133 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MDE60_RS22465 Protein ID WP_002886901.1
Coordinates 4629123..4629365 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MDE60_RS22435 (MDE60_22410) 4624266..4624529 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
MDE60_RS22440 (MDE60_22415) 4624659..4624832 + 174 WP_002886906.1 hypothetical protein -
MDE60_RS22445 (MDE60_22420) 4624835..4625578 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MDE60_RS22450 (MDE60_22425) 4625935..4628073 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MDE60_RS22455 (MDE60_22430) 4628381..4628845 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MDE60_RS22460 (MDE60_22435) 4628849..4629133 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MDE60_RS22465 (MDE60_22440) 4629123..4629365 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MDE60_RS22470 (MDE60_22445) 4629443..4631353 - 1911 WP_031593171.1 PRD domain-containing protein -
MDE60_RS22475 (MDE60_22450) 4631376..4632530 - 1155 WP_004178372.1 lactonase family protein -
MDE60_RS22480 (MDE60_22455) 4632597..4633337 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T235690 WP_009486548.1 NZ_CP092077:c4629133-4628849 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T235690 NZ_LR134326:c2524997-2524686 [Bordetella bronchiseptica]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAGCTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT235690 WP_002886901.1 NZ_CP092077:c4629365-4629123 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT235690 NZ_LR134326:c2524683-2524384 [Bordetella bronchiseptica]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References