Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797077..797734 Replicon chromosome
Accession NZ_CP092077
Organism Klebsiella pneumoniae strain P1-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MDE60_RS03965 Protein ID WP_002916310.1
Coordinates 797324..797734 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MDE60_RS03960 Protein ID WP_002916312.1
Coordinates 797077..797343 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MDE60_RS03935 (MDE60_03935) 792285..793718 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
MDE60_RS03940 (MDE60_03940) 793837..794565 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MDE60_RS03945 (MDE60_03945) 794615..794926 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MDE60_RS03950 (MDE60_03950) 795090..795749 + 660 WP_102011713.1 hemolysin III family protein -
MDE60_RS03955 (MDE60_03955) 795848..796831 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
MDE60_RS03960 (MDE60_03960) 797077..797343 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MDE60_RS03965 (MDE60_03965) 797324..797734 + 411 WP_002916310.1 protein YgfX Toxin
MDE60_RS03970 (MDE60_03970) 797741..798262 - 522 WP_004144730.1 flavodoxin FldB -
MDE60_RS03975 (MDE60_03975) 798363..799259 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MDE60_RS03980 (MDE60_03980) 799282..799995 + 714 WP_101862174.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MDE60_RS03985 (MDE60_03985) 800001..801734 + 1734 WP_102011714.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T235677 WP_002916310.1 NZ_CP092077:797324-797734 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T235677 NZ_LR134322:c521675-521490 [Lacticaseibacillus rhamnosus]
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT235677 WP_002916312.1 NZ_CP092077:797077-797343 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235677 NZ_LR134322:c521975-521703 [Lacticaseibacillus rhamnosus]
ATGACCAAAAAATCCCGCATCAGCGTTAGGATTGATACCAAAACTAAAGAACGAGCGCTCCATGTTCTTAATAGCATGGG
ATTAGATATTTCCTCGGCTATTAACATGTACCTGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACCTCCAATGT
CATTTGTTGATCAGCTTCAAGTTGCAGAAGCTGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTCGATGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References