Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 6840..7341 | Replicon | plasmid unnamed |
| Accession | NZ_CP092076 | ||
| Organism | Salmonella enterica strain P281972 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | A0A6X6XTU7 |
| Locus tag | MC377_RS23175 | Protein ID | WP_000702245.1 |
| Coordinates | 6840..7100 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | MC377_RS23180 | Protein ID | WP_001132407.1 |
| Coordinates | 7090..7341 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MC377_RS23130 (MC377_23130) | 2379..2531 | + | 153 | Protein_1 | DUF5431 family protein | - |
| MC377_RS23135 (MC377_23135) | 2476..2598 | + | 123 | WP_223685802.1 | Hok/Gef family protein | - |
| MC377_RS23140 (MC377_23140) | 2748..3344 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| MC377_RS23145 (MC377_23145) | 3362..3646 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| MC377_RS23150 (MC377_23150) | 3720..4385 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| MC377_RS23155 (MC377_23155) | 4983..5312 | + | 330 | WP_000855121.1 | hypothetical protein | - |
| MC377_RS23160 (MC377_23160) | 5893..6216 | + | 324 | WP_000427402.1 | hypothetical protein | - |
| MC377_RS23165 (MC377_23165) | 6257..6466 | + | 210 | WP_000866037.1 | hypothetical protein | - |
| MC377_RS23170 (MC377_23170) | 6564..6788 | + | 225 | WP_000814383.1 | hypothetical protein | - |
| MC377_RS23175 (MC377_23175) | 6840..7100 | + | 261 | WP_000702245.1 | hypothetical protein | Toxin |
| MC377_RS23180 (MC377_23180) | 7090..7341 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| MC377_RS23185 (MC377_23185) | 7891..8169 | + | 279 | WP_000545937.1 | hypothetical protein | - |
| MC377_RS23190 (MC377_23190) | 8365..8472 | - | 108 | Protein_13 | hypothetical protein | - |
| MC377_RS23195 (MC377_23195) | 8497..9705 | + | 1209 | WP_059260046.1 | RNA-guided endonuclease TnpB family protein | - |
| MC377_RS23200 (MC377_23200) | 9925..10191 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MC377_RS23205 (MC377_23205) | 10298..10741 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| MC377_RS23210 (MC377_23210) | 11038..11220 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| MC377_RS23215 (MC377_23215) | 11245..11682 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MC377_RS23220 (MC377_23220) | 11816..12001 | - | 186 | Protein_19 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..62386 | 62386 | |
| - | flank | IS/Tn | - | - | 8557..9705 | 1148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9818.23 Da Isoelectric Point: 9.5163
>T235674 WP_000702245.1 NZ_CP092076:6840-7100 [Salmonella enterica]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T235674 NZ_LR134321:2548149-2548319 [Shewanella baltica]
TTGTTTAAAGCATTAGGTGCAGACGTTTCCGAAAGAGCAGGCTCTCGAGTCGCTGTTGTGCTGTTTGATGAAGTACGAGT
ATTTCATCGGCCCCACCCATCTCCGAATACGGATAAAAGAGCAATTACCAGTATTTGGAAATGGCTAGAAGAGAACGAGG
TGAAACCATGA
TTGTTTAAAGCATTAGGTGCAGACGTTTCCGAAAGAGCAGGCTCTCGAGTCGCTGTTGTGCTGTTTGATGAAGTACGAGT
ATTTCATCGGCCCCACCCATCTCCGAATACGGATAAAAGAGCAATTACCAGTATTTGGAAATGGCTAGAAGAGAACGAGG
TGAAACCATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT235674 WP_001132407.1 NZ_CP092076:7090-7341 [Salmonella enterica]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT235674 NZ_LR134321:2548316-2548648 [Shewanella baltica]
ATGAACATAATGGTGGTTGACGGTTATAAGGCCAAAATTGAATATGACCCTCAACTCGATCAGTTTCGAGGAGAGATTCT
TGGACTTAATGGAAGTGCAGATTTTTACGGCACAAATCCTGCCAGTCTTCGTCGGGAATTCAAAAACTCACTCAAAGTAT
TCCTTGAAGTATGTAAAGAAAAGGGAATCAAACCAAGCAAGGAGTTTTCTGGAAAATTTAATCTTCGCATACCGCCGCAT
TTACATGCTGAAGTAGCTGCACGAGCTTCTGCTGAGGGCAAAAGTATCAATCAATGGGTTTCTGAAGTGCTCAGAAATTC
TGTAAGTGAGTAG
ATGAACATAATGGTGGTTGACGGTTATAAGGCCAAAATTGAATATGACCCTCAACTCGATCAGTTTCGAGGAGAGATTCT
TGGACTTAATGGAAGTGCAGATTTTTACGGCACAAATCCTGCCAGTCTTCGTCGGGAATTCAAAAACTCACTCAAAGTAT
TCCTTGAAGTATGTAAAGAAAAGGGAATCAAACCAAGCAAGGAGTTTTCTGGAAAATTTAATCTTCGCATACCGCCGCAT
TTACATGCTGAAGTAGCTGCACGAGCTTCTGCTGAGGGCAAAAGTATCAATCAATGGGTTTCTGAAGTGCTCAGAAATTC
TGTAAGTGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|