Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4227497..4228278 Replicon chromosome
Accession NZ_CP092075
Organism Salmonella enterica strain P281972

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag MC377_RS20920 Protein ID WP_000626104.1
Coordinates 4227497..4227988 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag MC377_RS20925 Protein ID WP_001110452.1
Coordinates 4227985..4228278 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC377_RS20890 (4223146) 4223146..4223895 - 750 WP_001747728.1 PTS sugar transporter subunit IIC -
MC377_RS20895 (4223948) 4223948..4224430 - 483 WP_000108906.1 PTS sugar transporter subunit IIB -
MC377_RS20900 (4224448) 4224448..4224837 - 390 WP_001639590.1 mannose/fructose/sorbose PTS transporter subunit IIA -
MC377_RS20905 (4225106) 4225106..4225917 + 812 Protein_4094 IS3 family transposase -
MC377_RS20910 (4226320) 4226320..4226406 + 87 Protein_4095 porin family protein -
MC377_RS20915 (4226497) 4226497..4227249 + 753 WP_024136566.1 non-specific acid phosphatase -
MC377_RS20920 (4227497) 4227497..4227988 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
MC377_RS20925 (4227985) 4227985..4228278 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
MC377_RS20930 (4228595) 4228595..4228817 + 223 Protein_4099 hypothetical protein -
MC377_RS20935 (4229083) 4229083..4229958 + 876 WP_000921674.1 AraC family transcriptional regulator -
MC377_RS20940 (4229955) 4229955..4230242 + 288 WP_001269916.1 transcriptional regulator RtsB -
MC377_RS20945 (4230382) 4230382..4230831 + 450 WP_238728174.1 Ig-like domain-containing protein -
MC377_RS20950 (4231119) 4231119..4232024 - 906 WP_086126459.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4202720..4230831 28111
- flank IS/Tn - - 4225106..4225768 662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T235671 WP_000626104.1 NZ_CP092075:c4227988-4227497 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T235671 NZ_LR134321:c1638390-1637974 [Shewanella baltica]
TTGAATGACATTATTATCAACAAAATAGCAACCATCAAACGCTGTATAAAACGCATCCAACAAGTTTATGGTGATGGCAG
CATGTTCAAACAAGACTTCACCCTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCAGTATCGACATAG
CAAACCATATTAACCGCCAACAACAACTGGGTATCCCCCAAAGTAGCCGTGATAGCTTTACACTACTTTCACAAAATAAA
ATAATTAATCAGCAGCTTGCAGACAACTTAAAGAAGATGGTTGGCCTAAGAAACATCGCAGTACATGACTATCAAGAACT
CAACCTCGATATCGTTGTGCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGAAGTGATAAAATTTTGTC
CAAGAATGAGTTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT235671 WP_001110452.1 NZ_CP092075:c4228278-4227985 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT235671 NZ_LR134321:c1638805-1638383 [Shewanella baltica]
ATGCAACAACTAAATGAAAGCATTATCATCAACTTACTACAAGATAACATCCCGCAGTTGAGATTGATCTACCTATTTGG
CTCCTATGCACAGGGCACGCAACACCGCAACAGTGATATCGATATTGCGGTACTCGCCGATGTCACTGTAGACAATATCG
CCCGCTGGCAACTTGCCCAAAAACTCGCCTCAGCGTTAGATACTGATGTTGATCTTGTTGATTTACGCACGGCATCCACA
GTGTTATGTCAGCAGGTAGTCACCCAAGGAAAGCGACTTTGGGGAACGCGACAAGATGATGAGATTTTTGCAGTGAAAAC
CATCTCAATGTACCAACATCTACAAGCTGAAAGACAAGCAATTATTGATGATGCAACGGCCAAAACAATAGCCAACGATC
ACAGGGGACGTCACTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References