Detailed information of TA system TA235670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4212996..4214694
• Replicon: chromosome
• Accession: NZ_CP092075
• Organism: Salmonella enterica strain P281972

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2T8TGC0
• Locus tag: MC377_RS20845
• Protein ID: WP_000365812.1
• Coordinates: 4213765..4214694 (+)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: MC377_RS20840
• Protein ID: WP_001134472.1
• Coordinates: 4212996..4213778 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC377_RS20815 (4209872)	4209872..4210093	-	222	WP_086126466.1	helix-turn-helix transcriptional regulator	-
MC377_RS20820 (4210090)	4210090..4210644	-	555	WP_000907649.1	ash family protein	-
MC377_RS20825 (4210901)	4210901..4211077	+	177	Protein_4078	XRE family transcriptional regulator	-
MC377_RS20830 (4211136)	4211136..4211693	-	558	WP_001012368.1	hypothetical protein	-
MC377_RS20835 (4211723)	4211723..4212694	-	972	WP_001029370.1	DUF4747 family protein	-
MC377_RS20840 (4212996)	4212996..4213778	+	783	WP_001134472.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
MC377_RS20845 (4213765)	4213765..4214694	+	930	WP_000365812.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MC377_RS20850 (4215253)	4215253..4215330	-	78	Protein_4083	helix-turn-helix domain-containing protein	-
MC377_RS20855 (4215336)	4215336..4215422	-	87	Protein_4084	reverse transcriptase/retron type	-
MC377_RS20860 (4216082)	4216082..4218802	+	2721	WP_086126465.1	sigma 54-interacting transcriptional regulator	-
MC377_RS20865 (4218844)	4218844..4219521	-	678	WP_000841834.1	D-allulose 6-phosphate 3-epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4202720..4230831	28111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-262)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35212.55 Da
• Isoelectric Point: 6.6435

>T235670 WP_000365812.1 NZ_CP092075:4213765-4214694 [Salmonella enterica]
MDLRDSYARQVRLLMTALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITESLNDR
PGISAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEIEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPITELLAPNWDTARITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDRDRQFLLRYKQNTPDWSLYRYPEIQHLPAIRWKSRNLAVLKDKNPAKYAAAVNKLERVLEQYL

Nucleotide

• Length: 930 bp

>T235670 NZ_LR134321:1309565-1310500 [Shewanella baltica]
ATGAATAAGTCATCGATATACTACCAGCAAGTGAGCTTGCTTATTCGGATGCTGCCGCTCGTCGCCCAAGAGAAGGTATT
TGCCCTAAAGGGCGGTACGGCTATCAACCTATTTGTACGCAACTTCCCACGCTTATCGGTCGATATCGATTTGGCTTATC
TTCCTTTGGAGCCAAGGGAACAAGCGCTACAAAGTGTGAAGGAAGCGCTTGGTCGTTTGACTGCGCAGATCAATCTACAA
CCGAACCTTAGTGCAGTATTTCAAGACAATAAATATGATGAGCTCAGGGTTGTCGTGACAAGTGATAGGGTGACAATAAA
AATTGAAGTCTCTCCTGTTGCGAGAGGTACACTACACAAAGCGGTATTAATGCCAGTCGTTGAGTTAGTTGAAGAGGAAT
TTGGGTATGCAGAGATCCCCGTTGTAAGCCTGCCTGATCTATACGGTGGTAAGTTATGTGCAGCGATGGATAGGCAGCAC
CCAAGGGATCTATTCGATGTGAAAATGCTGCTGGCGGAAGAGGGGATCAGTCGAGAGATTTTAGTCGGCTTTCTCACTTA
TACACTTAGCCATCCAAGACCCATTAATGAAGTGATGTCTCCACGTTGGAAACCGCTTGATGAAAGCTTTCAAACTGAAT
TCAATGGAATGACGACAAAGCCGATTAAACTCGATGAGCTGGTTTTAACTCGCTCAGAAATGCTAACAGCGTTGCAGCAT
CACTTTACCGCAAAGGACAGAGATTTTTTATTATCCTTTAAACAGGGTCAGCCTGATTGGTCATTGTTTGATGAACCGAG
CGTTGCGGCACTACCTGCGGTGAGATGGAAGCTATTGAATATCCAAAACCTAGCGAAAAATAAATCCAAGCATCAAGAAC
AACTCATTAAACTGGCTGATGTATTGGAGACGTGGGTTGCAGGTCGGATACTGTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29343.73 Da
• Isoelectric Point: 8.1107

>AT235670 WP_001134472.1 NZ_CP092075:4212996-4213778 [Salmonella enterica]
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRMAGLT
SLALQGYAHYTEPGRPQVWLALPAYAKLPGWFVAFEQSAMFVTLYTSGLTVDITPFTTKLNIGDRQLIGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT235670 NZ_LR134321:1308784-1309572 [Shewanella baltica]
ATGTCATCAAAAATAAACTGGCTGATTAATCATACGAGCCCTGGTGCGGTAGTGCTTCAGTCGTGGTTGACACAAAATGA
GATCAGCTCATCTTTGGTGAGAAAATATGTGCAGAGTGGTTGGTTGTACAAGATAAGTGCGGGGGTTTACGTTCGTCCTG
AGTCAACAGGTAAGTTACAGCCTCATTGGGTTGAAGCGCTCAAGGCTGTGAATGAGCAGCTAAAGCTTCCTGTTCACCTT
GCGGGAGTCAGTAGCCTAACGCATCAAGGGCTTAGTCATTATCTTCAACTAAGCAGCGAGCAAGTTTGGGTTGGCTGTCA
AAGTAAGCAGGCGTTGCCAAAGTGGTTCCGCGAATTGGAGGAGCAAAATTGGCTTTTCTATACCAGTAGCAAGCTGACCC
AAACGTTGGAAAAAGACTTTATTACTATAGGGGTGAACAATAGGGAAGTTAAGGCAAGTTGTGCGGAGCTTGCAGCCTAT
GAGGTCGTCAATGCCATTGGCAAACATATCAGTTTTGAGCATGCCGCGGAGCTGTTTCAAGGGTTAGTGAATCTCAGCCC
ACGTAAAATACAGTCAATACTGAATCGAAGTGAATCCGTACAAGCTAATCGCGTATTTCTCTTTTTAGGCCACTACTATC
AACACCAGTGGAGCAAAAGGTTAGATGAGCAGCAAATCACGCTTGGTGCGGGAAAGCGTCAGGTGGTGGCTCATGGCCGT
TACGATGGACGGTATCAAATAACAGTGCCTGCATCGTTTATTAAGACAGAAGAAAATCAATATGAATAA

Structures

Toxin

• AlphaFold DB: A0A2T8TGC0