Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1872828..1873319 Replicon chromosome
Accession NC_011999
Organism Macrococcus caseolyticus JCSC5402

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MCCL_RS09750 Protein ID WP_041636190.1
Coordinates 1872828..1873178 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MCCL_RS12105 Protein ID WP_101031708.1
Coordinates 1873179..1873319 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCCL_RS09725 1867932..1870067 - 2136 WP_041636189.1 RNA-binding transcriptional accessory protein -
MCCL_RS09730 1870144..1870911 - 768 WP_015912228.1 RNA polymerase sigma factor SigB -
MCCL_RS09735 1870916..1871359 - 444 WP_015912229.1 anti-sigma B factor RsbW -
MCCL_RS09740 1871364..1871687 - 324 WP_015912230.1 anti-sigma factor antagonist -
MCCL_RS09745 1871772..1872779 - 1008 WP_015912231.1 PP2C family protein-serine/threonine phosphatase -
MCCL_RS09750 1872828..1873178 - 351 WP_041636190.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MCCL_RS12105 1873179..1873319 - 141 WP_101031708.1 antitoxin MazE Antitoxin
MCCL_RS09755 1873380..1874522 - 1143 WP_015912233.1 alanine racemase -
MCCL_RS09760 1874548..1874904 - 357 WP_015912234.1 holo-ACP synthase -
MCCL_RS09765 1874846..1875367 - 522 WP_015912235.1 PH domain-containing protein -
MCCL_RS09770 1875351..1876862 - 1512 WP_015912236.1 PH domain-containing protein -
MCCL_RS09775 1876852..1877328 - 477 WP_041636191.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12687.86 Da        Isoelectric Point: 9.9422

>T23567 WP_041636190.1 NC_011999:c1873178-1872828 [Macrococcus caseolyticus JCSC5402]
MKRGDVFLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKATHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T23567 NC_011999:c1873178-1872828 [Macrococcus caseolyticus JCSC5402]
ATGAAACGCGGAGATGTTTTTTTGGCTGATCTGTCACCAGTGAAGGGATCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATAGGGAATAAATATAGTCCCACTGTGATTGTAGCGGCAATTACTGCAAAGATTAATAAGGCAAAAA
TCCCCACCCATGTTGAAATTGGCAAGGCAACGCATCACTTAGAAAAGGATTCGGTAATACTGCTGGAACAAATTAGAACC
ATTGATAAGAATAGGTTGATTGATCATTTAACTGTGCTTGATAAGGCGAAGATGAAAGAAGTGGATACTGCACTTATAAT
TAGTTTAGGTTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5326.88 Da        Isoelectric Point: 3.8301

>AT23567 WP_101031708.1 NC_011999:c1873319-1873179 [Macrococcus caseolyticus JCSC5402]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNHQTYTFDGE

Download         Length: 141 bp

>AT23567 NC_011999:c1873319-1873179 [Macrococcus caseolyticus JCSC5402]
ATGAGCCAGAAGCTAGAACAGATGCTGATAGAAGGTTATCAATCAATGGCAGAGATAAATTTATCGATAGCATCAGAACA
TTATGTATTAGAATGCGAAGTTACTGATAACCATCAGACATATACCTTTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References