Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4097828..4098344 Replicon chromosome
Accession NZ_CP092075
Organism Salmonella enterica strain P281972

Toxin (Protein)


Gene name relE Uniprot ID A0A2T8TGU4
Locus tag MC377_RS20235 Protein ID WP_000220576.1
Coordinates 4097828..4098112 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MC377_RS20240 Protein ID WP_000212724.1
Coordinates 4098102..4098344 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC377_RS20220 (4092946) 4092946..4094598 + 1653 WP_000155063.1 alpha,alpha-phosphotrehalase -
MC377_RS20225 (4095007) 4095007..4097145 + 2139 WP_086126515.1 anaerobic ribonucleoside-triphosphate reductase -
MC377_RS20230 (4097360) 4097360..4097824 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MC377_RS20235 (4097828) 4097828..4098112 - 285 WP_000220576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MC377_RS20240 (4098102) 4098102..4098344 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MC377_RS20245 (4098422) 4098422..4100334 - 1913 Protein_3966 BglG family transcription antiterminator -
MC377_RS20250 (4100351) 4100351..4101091 - 741 WP_000779265.1 KDGP aldolase family protein -
MC377_RS20255 (4101088) 4101088..4102206 - 1119 WP_001139180.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MC377_RS20260 (4102190) 4102190..4103323 - 1134 WP_000459931.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10855.65 Da        Isoelectric Point: 9.8739

>T235669 WP_000220576.1 NZ_CP092075:c4098112-4097828 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T235669 NZ_LR134321:703005-704306 [Shewanella baltica]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATTATCGGGGAGTTATCCTTTGATGCGATGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGGAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGTGCAATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGCTTGCGGGTGTGCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGTGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCTGTAAAATGTCGCAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGGCGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCTATGGCAATTGA
TGATGAATTTGATCCAAATAGTATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGATTTACCAAAGAATTTAT
TAATCAGTAACTTAACGACAATGGCGCGAAGAATCTCGCAGGCAATAGATGGTGTGATTTCAATGCTCCCAGCCCTCGAT
GAGAGTGAAACAGTATTTGTGGCTCATTATAAAGTGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCTGCTGA
GATCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT235669 WP_000212724.1 NZ_CP092075:c4098344-4098102 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT235669 NZ_LR134321:702765-703001 [Shewanella baltica]
ATGGCATCACCGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCAGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGAGATCGTTTCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TGU4

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References