Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4040145..4040695 Replicon chromosome
Accession NZ_CP092075
Organism Salmonella enterica strain P281972

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MC377_RS19950 Protein ID WP_001199743.1
Coordinates 4040145..4040453 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag MC377_RS19955 Protein ID WP_000016244.1
Coordinates 4040456..4040695 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC377_RS19940 (4035549) 4035549..4039064 - 3516 WP_238727947.1 AAA domain-containing protein -
MC377_RS19945 (4039426) 4039426..4039710 - 285 Protein_3908 Arm DNA-binding domain-containing protein -
MC377_RS19950 (4040145) 4040145..4040453 - 309 WP_001199743.1 CcdB family protein Toxin
MC377_RS19955 (4040456) 4040456..4040695 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MC377_RS19960 (4040808) 4040808..4041056 - 249 WP_020898324.1 ribbon-helix-helix protein, CopG family -
MC377_RS19965 (4041121) 4041121..4041954 - 834 WP_193432508.1 DUF4942 domain-containing protein -
MC377_RS19970 (4042095) 4042095..4042717 - 623 Protein_3913 metallophosphoesterase -
MC377_RS19975 (4042759) 4042759..4043112 - 354 WP_001181796.1 TA system toxin CbtA family protein -
MC377_RS19980 (4043127) 4043127..4043455 - 329 Protein_3915 type IV toxin-antitoxin system YeeU family antitoxin -
MC377_RS19985 (4043479) 4043479..4043700 - 222 WP_000691987.1 DUF987 family protein -
MC377_RS19990 (4043697) 4043697..4044197 - 501 WP_000100794.1 DNA repair protein RadC -
MC377_RS19995 (4044216) 4044216..4045037 - 822 WP_000197551.1 DUF932 domain-containing protein -
MC377_RS20000 (4045121) 4045121..4045483 - 363 WP_000393539.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4027454..4056402 28948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T235668 WP_001199743.1 NZ_CP092075:c4040453-4040145 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T235668 NZ_LR134321:413137-414444 [Shewanella baltica]
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGGGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAATGGCTAGCGATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCCGCTACGCAAGCAAGCCTATAAAG
GTGATGAAGTTTATAACTTCTTCGATAATTTGCTACCTGATAATCACGAAGTGAAAAACAGAGTCGTTGCTCGTCATAAT
GCTGATTCGACACAAGCGTTTGACTTACTGGCTAAAATTGGTCAAGACAGTGTGGGTGCATTACAGCTTGTCCCCCATGG
TCAGCCCCCCTTTGATACCAAAAAAATTGAGTCTAAACCGCTATCCGATAAGCAGTTGGAAAAAGTACTCAAGGGTTATC
AGTCCAATATCCCCTTAGGCATGCTAGCCGATGACGATGACTTTAGGATTTCTATTGCCGGTGCCCAAGAAAAGACGGCA
TTACTGAAACTCAATGGAGAGTGGCGATTACCTATCAAATCGACACCCACTACCCATATCATTAAGCTGCCCATAGGTGA
AATAAACAGCCACTCCCACAGCATAGATATGTCAGACAGTGTCGAGAATGAATACCTGTGCATGATGATAGTCAGAGAGT
TTGGTTTAGATGCACCCCAGTGCTCAATAATCAAAGTGGGTGATATTAAAGCGCTTGCTGTGGAGCGATTCGATCGCAGG
CTCTCTTCAGATGGCACATGGATTATGCGGCTGCCCCAAGAGGACTTTTGTCAGGCATTAAATATTCCACCAGCGAAGAA
ATATGAGAGCCTTGGTGGCCCGGGTATTGAACAAATTATGCCTTATCTATTGGGTTCGATGAACTCGGAGCGCGACAGAT
ATAACTTCATCAAGTCTCAGGTTTTGTTTTGGCTTTTAGCCGCAACCGATGGTCATGCTAAAAACTTCTCACTCTTCATC
GAGGCCGATGGCGGATATCGACTAACGCCTTTTTACGATATTTTATCCATGTACCCTGTTATTGGTGGTAAAGGCTTAAA
TATTCGTGATGCCAAGCTCGCTATGGGCCTCAAAGCGGCTAAGGGTAAGAAGTATCAAATCAATCAAATTTTTCCACGGC
ACTTTATCCTAACAGCTAAAGCTGTGGGCTTTGATACTGGGATTATGATGGAGATGATGCGCGACATTGCTGACAAGGTA
GAGGCTGTGGTTGTTAAGGTTAAAGCGCAGCTGCCAGATGATTTTCCACCACACATACAGGATTCAATATTGAACGGTTT
AACTGACAGAATTAAGCGTATAGCTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT235668 WP_000016244.1 NZ_CP092075:c4040695-4040456 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT235668 NZ_LR134321:412856-413137 [Shewanella baltica]
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCAAGCTTTGAGTTGAATCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCTACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References