Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4040145..4040695 | Replicon | chromosome |
Accession | NZ_CP092075 | ||
Organism | Salmonella enterica strain P281972 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | M7RJ32 |
Locus tag | MC377_RS19950 | Protein ID | WP_001199743.1 |
Coordinates | 4040145..4040453 (-) | Length | 103 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V7ITQ8 |
Locus tag | MC377_RS19955 | Protein ID | WP_000016244.1 |
Coordinates | 4040456..4040695 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MC377_RS19940 (4035549) | 4035549..4039064 | - | 3516 | WP_238727947.1 | AAA domain-containing protein | - |
MC377_RS19945 (4039426) | 4039426..4039710 | - | 285 | Protein_3908 | Arm DNA-binding domain-containing protein | - |
MC377_RS19950 (4040145) | 4040145..4040453 | - | 309 | WP_001199743.1 | CcdB family protein | Toxin |
MC377_RS19955 (4040456) | 4040456..4040695 | - | 240 | WP_000016244.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
MC377_RS19960 (4040808) | 4040808..4041056 | - | 249 | WP_020898324.1 | ribbon-helix-helix protein, CopG family | - |
MC377_RS19965 (4041121) | 4041121..4041954 | - | 834 | WP_193432508.1 | DUF4942 domain-containing protein | - |
MC377_RS19970 (4042095) | 4042095..4042717 | - | 623 | Protein_3913 | metallophosphoesterase | - |
MC377_RS19975 (4042759) | 4042759..4043112 | - | 354 | WP_001181796.1 | TA system toxin CbtA family protein | - |
MC377_RS19980 (4043127) | 4043127..4043455 | - | 329 | Protein_3915 | type IV toxin-antitoxin system YeeU family antitoxin | - |
MC377_RS19985 (4043479) | 4043479..4043700 | - | 222 | WP_000691987.1 | DUF987 family protein | - |
MC377_RS19990 (4043697) | 4043697..4044197 | - | 501 | WP_000100794.1 | DNA repair protein RadC | - |
MC377_RS19995 (4044216) | 4044216..4045037 | - | 822 | WP_000197551.1 | DUF932 domain-containing protein | - |
MC377_RS20000 (4045121) | 4045121..4045483 | - | 363 | WP_000393539.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4027454..4056402 | 28948 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11845.67 Da Isoelectric Point: 6.7228
>T235668 WP_001199743.1 NZ_CP092075:c4040453-4040145 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
Download Length: 309 bp
>T235668 NZ_LR134321:413137-414444 [Shewanella baltica]
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGGGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAATGGCTAGCGATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCCGCTACGCAAGCAAGCCTATAAAG
GTGATGAAGTTTATAACTTCTTCGATAATTTGCTACCTGATAATCACGAAGTGAAAAACAGAGTCGTTGCTCGTCATAAT
GCTGATTCGACACAAGCGTTTGACTTACTGGCTAAAATTGGTCAAGACAGTGTGGGTGCATTACAGCTTGTCCCCCATGG
TCAGCCCCCCTTTGATACCAAAAAAATTGAGTCTAAACCGCTATCCGATAAGCAGTTGGAAAAAGTACTCAAGGGTTATC
AGTCCAATATCCCCTTAGGCATGCTAGCCGATGACGATGACTTTAGGATTTCTATTGCCGGTGCCCAAGAAAAGACGGCA
TTACTGAAACTCAATGGAGAGTGGCGATTACCTATCAAATCGACACCCACTACCCATATCATTAAGCTGCCCATAGGTGA
AATAAACAGCCACTCCCACAGCATAGATATGTCAGACAGTGTCGAGAATGAATACCTGTGCATGATGATAGTCAGAGAGT
TTGGTTTAGATGCACCCCAGTGCTCAATAATCAAAGTGGGTGATATTAAAGCGCTTGCTGTGGAGCGATTCGATCGCAGG
CTCTCTTCAGATGGCACATGGATTATGCGGCTGCCCCAAGAGGACTTTTGTCAGGCATTAAATATTCCACCAGCGAAGAA
ATATGAGAGCCTTGGTGGCCCGGGTATTGAACAAATTATGCCTTATCTATTGGGTTCGATGAACTCGGAGCGCGACAGAT
ATAACTTCATCAAGTCTCAGGTTTTGTTTTGGCTTTTAGCCGCAACCGATGGTCATGCTAAAAACTTCTCACTCTTCATC
GAGGCCGATGGCGGATATCGACTAACGCCTTTTTACGATATTTTATCCATGTACCCTGTTATTGGTGGTAAAGGCTTAAA
TATTCGTGATGCCAAGCTCGCTATGGGCCTCAAAGCGGCTAAGGGTAAGAAGTATCAAATCAATCAAATTTTTCCACGGC
ACTTTATCCTAACAGCTAAAGCTGTGGGCTTTGATACTGGGATTATGATGGAGATGATGCGCGACATTGCTGACAAGGTA
GAGGCTGTGGTTGTTAAGGTTAAAGCGCAGCTGCCAGATGATTTTCCACCACACATACAGGATTCAATATTGAACGGTTT
AACTGACAGAATTAAGCGTATAGCTTAG
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGGGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAATGGCTAGCGATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCCGCTACGCAAGCAAGCCTATAAAG
GTGATGAAGTTTATAACTTCTTCGATAATTTGCTACCTGATAATCACGAAGTGAAAAACAGAGTCGTTGCTCGTCATAAT
GCTGATTCGACACAAGCGTTTGACTTACTGGCTAAAATTGGTCAAGACAGTGTGGGTGCATTACAGCTTGTCCCCCATGG
TCAGCCCCCCTTTGATACCAAAAAAATTGAGTCTAAACCGCTATCCGATAAGCAGTTGGAAAAAGTACTCAAGGGTTATC
AGTCCAATATCCCCTTAGGCATGCTAGCCGATGACGATGACTTTAGGATTTCTATTGCCGGTGCCCAAGAAAAGACGGCA
TTACTGAAACTCAATGGAGAGTGGCGATTACCTATCAAATCGACACCCACTACCCATATCATTAAGCTGCCCATAGGTGA
AATAAACAGCCACTCCCACAGCATAGATATGTCAGACAGTGTCGAGAATGAATACCTGTGCATGATGATAGTCAGAGAGT
TTGGTTTAGATGCACCCCAGTGCTCAATAATCAAAGTGGGTGATATTAAAGCGCTTGCTGTGGAGCGATTCGATCGCAGG
CTCTCTTCAGATGGCACATGGATTATGCGGCTGCCCCAAGAGGACTTTTGTCAGGCATTAAATATTCCACCAGCGAAGAA
ATATGAGAGCCTTGGTGGCCCGGGTATTGAACAAATTATGCCTTATCTATTGGGTTCGATGAACTCGGAGCGCGACAGAT
ATAACTTCATCAAGTCTCAGGTTTTGTTTTGGCTTTTAGCCGCAACCGATGGTCATGCTAAAAACTTCTCACTCTTCATC
GAGGCCGATGGCGGATATCGACTAACGCCTTTTTACGATATTTTATCCATGTACCCTGTTATTGGTGGTAAAGGCTTAAA
TATTCGTGATGCCAAGCTCGCTATGGGCCTCAAAGCGGCTAAGGGTAAGAAGTATCAAATCAATCAAATTTTTCCACGGC
ACTTTATCCTAACAGCTAAAGCTGTGGGCTTTGATACTGGGATTATGATGGAGATGATGCGCGACATTGCTGACAAGGTA
GAGGCTGTGGTTGTTAAGGTTAAAGCGCAGCTGCCAGATGATTTTCCACCACACATACAGGATTCAATATTGAACGGTTT
AACTGACAGAATTAAGCGTATAGCTTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 8709.86 Da Isoelectric Point: 6.4633
>AT235668 WP_000016244.1 NZ_CP092075:c4040695-4040456 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
Download Length: 240 bp
>AT235668 NZ_LR134321:412856-413137 [Shewanella baltica]
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCAAGCTTTGAGTTGAATCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCTACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCAAGCTTTGAGTTGAATCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCTACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6C6Z9V9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I5T4R8 |