Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3439949..3440569 Replicon chromosome
Accession NZ_CP092075
Organism Salmonella enterica strain P281972

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MC377_RS17185 Protein ID WP_001280991.1
Coordinates 3440351..3440569 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MC377_RS17180 Protein ID WP_000344807.1
Coordinates 3439949..3440323 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC377_RS17170 (3435088) 3435088..3436281 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MC377_RS17175 (3436304) 3436304..3439453 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MC377_RS17180 (3439949) 3439949..3440323 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MC377_RS17185 (3440351) 3440351..3440569 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MC377_RS17190 (3440749) 3440749..3441300 + 552 WP_001278792.1 maltose O-acetyltransferase -
MC377_RS17195 (3441418) 3441418..3441888 + 471 WP_000136183.1 YlaC family protein -
MC377_RS17200 (3441943) 3441943..3442083 - 141 WP_001197748.1 type B 50S ribosomal protein L36 -
MC377_RS17205 (3442089) 3442089..3442349 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
MC377_RS17210 (3442574) 3442574..3444124 + 1551 WP_000213153.1 EAL domain-containing protein -
MC377_RS17220 (3444355) 3444355..3444744 + 390 WP_000961283.1 MGMT family protein -
MC377_RS17225 (3444777) 3444777..3445346 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235667 WP_001280991.1 NZ_CP092075:3440351-3440569 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235667 NZ_LR134320:c1649283-1649092 [Streptococcus mutans]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235667 WP_000344807.1 NZ_CP092075:3439949-3440323 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235667 NZ_LR134320:c1649074-1648697 [Streptococcus mutans]
ATGTTAAAATCATATCCTGCAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACCGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References