Detailed information of TA system TA235657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 942507..943321
• Replicon: chromosome
• Accession: NZ_CP092075
• Organism: Salmonella enterica strain P281972

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: MC377_RS04525
• Protein ID: WP_086126752.1
• Coordinates: 942507..943034 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: MC377_RS04530
• Protein ID: WP_000855694.1
• Coordinates: 943031..943321 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC377_RS04505 (937807)	937807..940374	-	2568	WP_050187062.1	DNA mismatch repair protein MutS	-
MC377_RS04510 (940533)	940533..941054	+	522	WP_000858994.1	hypothetical protein	-
MC377_RS04515 (941226)	941226..941882	-	657	WP_000420459.1	protein-serine/threonine phosphatase	-
MC377_RS04520 (942232)	942232..942434	+	203	Protein_888	IS5/IS1182 family transposase	-
MC377_RS04525 (942507)	942507..943034	-	528	WP_086126752.1	GNAT family N-acetyltransferase	Toxin
MC377_RS04530 (943031)	943031..943321	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
MC377_RS04535 (943591)	943591..943791	-	201	Protein_891	transposase	-
MC377_RS04540 (944032)	944032..944358	+	327	WP_086126753.1	hypothetical protein	-
MC377_RS04545 (944631)	944631..944977	-	347	Protein_893	DUF1493 family protein	-
MC377_RS04550 (944962)	944962..945411	-	450	WP_079959869.1	hypothetical protein	-
MC377_RS04555 (945843)	945843..946286	-	444	WP_086126754.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
MC377_RS04560 (946744)	946744..947394	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	941226..952707	11481
	-	flank	IS/Tn	-	-	942258..942434	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19038.89 Da
• Isoelectric Point: 9.6420

>T235657 WP_086126752.1 NZ_CP092075:c943034-942507 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIPAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T235657 NZ_LR134316:2201368-2202204 [Streptococcus dysgalactiae subsp. equisimilis]
GTGAACAAAGCAAAATTAACGGCGCTCTGCCATAAAGTTTCAAAAGAAACAGGATTAACGTTTAATTCTGTGATGACCTA
CTACTTTCTGGAAATTATTCTGAAAAAATTGAGCCAAAGCGCTTATGCTCAAAATTACATTTTCAAAGGAGGTTTTCTGC
TCTCAAATGTCGTCGGGGTTGCTTCCCGTAGTACCGTTGACATTGACTTTCTCTTTAGTAAAATGAATCTATCAGAAGAG
ACCGTGCATCAGCAATTGGAGGATATCCTTGGAAAATCTGATGAAGATATTTCTTTCACTATTCAGTCGGTCACAGCAAT
TAAGGAAAGTGATGATTATGGAGGATATCGTGCAAGTATCCTTTGCCAGCTTGAGAACATCAGACAAGTCATCCACCTGG
ATATCGCAACTGGGGACATTGTCACTCCGCAGCCCATCACTTACGATTACAAGCCAATCTTCACATCAGAACAGTTTCCT
ATCATTGCCTACACGATTGAGACTATCTTAGCAGAGAAACTACAAACTATTTATTCTCGCAGCTTCTTGAATAGTCGAAG
CAAAGACTTCTATGACATCTATATCTTGTCAAAATTGAAGAAATCAGAAATTGATTCGCAACAACTTCTCACTGCTTGTC
AGCGTACCTTCGATTATCGAGGTACTGAATTAGACTTCGATAAATTCATCAATCTGCTAGAAACATTCAAAACAGATTCA
ACCCAAAACCATCAGTGGGAAAACTACTCTAAAAAGTATAGTTACACTAAAGGTATTACATTTAACGATGTTCTGACAGA
GATGACTGATTTGCTTGTAACTATCAAAAATCTCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT235657 WP_000855694.1 NZ_CP092075:c943321-943031 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT235657 NZ_LR134316:2200781-2201371 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTCTAATAAAGAAACCGTTCTGAATTATCTCAAACAAAATAACGGTATCATTACATATAAAGACTGTAAAGAGCTTGG
GGTTCCAGCTGTCTATCTCTCACGACTTGAAAATGAAGAGAAAATATTCCGAGTGGACAAGGGCATCTATCTTTCTACCG
ATGGTGACTATGACGAGTACTACTTCTTCCAATACAGATTTTCAAGAGCTATTTACTCCTATGTTTCCGCTCTTTATCTT
CAAGGGTTCACGGATGAAATCCCTCAATATTTTGAAGTCACCGTACCAAGAGGGTATCGTTTCAATAATCCGCCTCAAAA
CCTTGCGGTTCATACCGTCCCAAAGGAAATTGTTGACCTTGGTATTATCTCTATAAAGACACCCTGGGGACAGACCGTTA
AGACCTACGACTTTGAGCGTATCATCTGTGACTTTATTCAAAATCGTAAAAAAATTGATAATGAACTTTTCGTCAAAACT
CTTAAGGCTTATGTCAACTATCCAAATAAAAACCTGACAAACCTTTACCAATACGCTGAAAAAATGAAAATTATCAATCA
AACAAAACAAACACTTGAGGTGCTAATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7