Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 797830..798455 Replicon chromosome
Accession NZ_CP092075
Organism Salmonella enterica strain P281972

Toxin (Protein)


Gene name vapC Uniprot ID A0A2T8TEJ4
Locus tag MC377_RS03880 Protein ID WP_000911339.1
Coordinates 798057..798455 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2T8TEJ6
Locus tag MC377_RS03875 Protein ID WP_000557547.1
Coordinates 797830..798057 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC377_RS03845 (792893) 792893..793991 + 1099 WP_010989230.1 peptide chain release factor 2 -
MC377_RS03850 (794001) 794001..795518 + 1518 WP_000003339.1 lysine--tRNA ligase -
MC377_RS03855 (795594) 795594..796139 - 546 WP_000133991.1 isopentenyl-diphosphate Delta-isomerase -
MC377_RS03860 (796404) 796404..797162 + 759 WP_000244328.1 amidase activator ActS -
MC377_RS03870 (797408) 797408..797621 - 214 Protein_760 hypothetical protein -
MC377_RS03875 (797830) 797830..798057 + 228 WP_000557547.1 toxin-antitoxin system antitoxin VapB Antitoxin
MC377_RS03880 (798057) 798057..798455 + 399 WP_000911339.1 tRNA(fMet)-specific endonuclease VapC Toxin
MC377_RS03885 (799262) 799262..799798 + 537 WP_001038505.1 STM3031 family outer membrane protein -
MC377_RS03890 (799845) 799845..800477 + 633 WP_000835261.1 YfdX family protein -
MC377_RS03895 (801196) 801196..801786 + 591 WP_001244641.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 797830..807613 9783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15043.39 Da        Isoelectric Point: 7.7785

>T235656 WP_000911339.1 NZ_CP092075:798057-798455 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHVRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T235656 NZ_LR134315:c4438214-4437903 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8572.55 Da        Isoelectric Point: 4.7318

>AT235656 WP_000557547.1 NZ_CP092075:797830-798057 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEDASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT235656 NZ_LR134315:c4437902-4437612 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TEJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T8TEJ6

References