Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 194302..195062 Replicon chromosome
Accession NZ_CP092075
Organism Salmonella enterica strain P281972

Toxin (Protein)


Gene name tacT Uniprot ID A0A2T8TB76
Locus tag MC377_RS00925 Protein ID WP_000533914.1
Coordinates 194577..195062 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MC377_RS00920 Protein ID WP_000965886.1
Coordinates 194302..194589 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC377_RS00900 (189707) 189707..190618 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
MC377_RS00905 (190628) 190628..192697 + 2070 WP_001291749.1 glycine--tRNA ligase subunit beta -
MC377_RS00910 (193087) 193087..193515 + 429 Protein_182 IS3 family transposase -
MC377_RS00915 (193657) 193657..194124 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
MC377_RS00920 (194302) 194302..194589 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MC377_RS00925 (194577) 194577..195062 + 486 WP_000533914.1 GNAT family N-acetyltransferase Toxin
MC377_RS00930 (195435) 195435..195974 - 540 WP_000047139.1 copper-binding periplasmic metallochaperone CueP -
MC377_RS00935 (196151) 196151..196363 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MC377_RS00940 (196651) 196651..196941 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MC377_RS00945 (197380) 197380..198090 + 711 WP_080097268.1 DUF3053 domain-containing protein -
MC377_RS00950 (198140) 198140..199114 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
MC377_RS00955 (199333) 199333..199995 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.36 Da        Isoelectric Point: 9.5819

>T235653 WP_000533914.1 NZ_CP092075:194577-195062 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTQQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T235653 NZ_LR134315:c3900750-3900463 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT235653 WP_000965886.1 NZ_CP092075:194302-194589 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT235653 NZ_LR134315:c3900476-3900174 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCTCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGTCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TB76

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References