Detailed information of TA system TA235652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 277998..278538
• Replicon: chromosome
• Accession: NZ_CP092074
• Organism: Emticicia sp. 21SJ11W-3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MB380_RS01170
• Protein ID: WP_253532314.1
• Coordinates: 277998..278291 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: MB380_RS01175
• Protein ID: WP_253532315.1
• Coordinates: 278293..278538 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MB380_RS01155 (MB380_01155)	273002..274543	+	1542	WP_253532308.1	YifB family Mg chelatase-like AAA ATPase	-
MB380_RS01160 (MB380_01160)	274641..276098	-	1458	WP_253532310.1	Gfo/Idh/MocA family oxidoreductase	-
MB380_RS01165 (MB380_01165)	276302..277828	-	1527	WP_253532312.1	acetylxylan esterase	-
MB380_RS01170 (MB380_01170)	277998..278291	-	294	WP_253532314.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MB380_RS01175 (MB380_01175)	278293..278538	-	246	WP_253532315.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MB380_RS01180 (MB380_01180)	278645..279988	-	1344	WP_253532317.1	TolC family protein	-
MB380_RS01185 (MB380_01185)	279988..281079	-	1092	WP_253532318.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11291.79 Da
• Isoelectric Point: 6.4810

>T235652 WP_253532314.1 NZ_CP092074:c278291-277998 [Emticicia sp. 21SJ11W-3]
MSEYRISQLAQQDLEDIWDYTIHEWSREQADKYIEGILASFNSIANGHAIGKPIDYVLPGYKKALYGKHYIFYRISSEGI
TEIIRISHVSIDVKNRL

Nucleotide

• Length: 294 bp

>T235652 NZ_LR134315:3572121-3572399 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9243.43 Da
• Isoelectric Point: 8.6381

>AT235652 WP_253532315.1 NZ_CP092074:c278538-278293 [Emticicia sp. 21SJ11W-3]
MSKNTSISIGSHFDSFIQRQIEAGRYASTSEVIRAGLRLLEQEEEKLKLLKQALREGEQSGFVEGFNPQEFQEKLRRKSV
G

Nucleotide

• Length: 246 bp

>AT235652 NZ_LR134315:3571858-3572118 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA