235648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2101983..2102497 Replicon chromosome
Accession NZ_CP092072
Organism Staphylococcus argenteus strain 1710042798

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag MCF40_RS10030 Protein ID WP_000233591.1
Coordinates 2101983..2102192 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MCF40_RS10035 Protein ID WP_000138932.1
Coordinates 2102204..2102497 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCF40_RS10010 (2097318) 2097318..2098682 - 1365 WP_031787694.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MCF40_RS10015 (2098697) 2098697..2099767 - 1071 WP_031787695.1 D-alanine--D-alanine ligase -
MCF40_RS10020 (2100086) 2100086..2101288 + 1203 WP_031787696.1 FtsW/RodA/SpoVE family cell cycle protein -
MCF40_RS10025 (2101717) 2101717..2101854 - 138 WP_000828355.1 Lmo0850 family protein -
MCF40_RS10030 (2101983) 2101983..2102192 - 210 WP_000233591.1 heavy metal-associated domain-containing protein Toxin
MCF40_RS10035 (2102204) 2102204..2102497 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MCF40_RS10040 (2102665) 2102665..2104149 + 1485 WP_031787697.1 cardiolipin synthase -
MCF40_RS10045 (2104178) 2104178..2104825 + 648 WP_031787698.1 HD domain-containing protein -
MCF40_RS10050 (2105420) 2105420..2106289 - 870 WP_000725805.1 membrane protein insertase YidC -
MCF40_RS10055 (2106375) 2106375..2107016 - 642 WP_031787699.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T235648 WP_000233591.1 NZ_CP092072:c2102192-2101983 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T235648 NZ_LR134315:2580129-2580236 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT235648 WP_000138932.1 NZ_CP092072:c2102497-2102204 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT235648 NZ_LR134315:c2580082-2580016 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References