Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2081847..2082376 Replicon chromosome
Accession NZ_CP092072
Organism Staphylococcus argenteus strain 1710042798

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U7JQG1
Locus tag MCF40_RS09945 Protein ID WP_000621178.1
Coordinates 2081847..2082209 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MCF40_RS09950 Protein ID WP_000948331.1
Coordinates 2082206..2082376 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCF40_RS09925 (2078829) 2078829..2079599 - 771 WP_001041104.1 RNA polymerase sigma factor SigB -
MCF40_RS09930 (2079574) 2079574..2080053 - 480 WP_001190826.1 anti-sigma B factor RsbW -
MCF40_RS09935 (2080055) 2080055..2080381 - 327 WP_001052491.1 anti-sigma factor antagonist -
MCF40_RS09940 (2080498) 2080498..2081499 - 1002 WP_000390825.1 PP2C family protein-serine/threonine phosphatase -
MCF40_RS09945 (2081847) 2081847..2082209 - 363 WP_000621178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MCF40_RS09950 (2082206) 2082206..2082376 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MCF40_RS09955 (2082461) 2082461..2083609 - 1149 WP_001281137.1 alanine racemase -
MCF40_RS09960 (2083679) 2083679..2084038 - 360 WP_031787685.1 holo-ACP synthase -
MCF40_RS09965 (2084042) 2084042..2084545 - 504 WP_031787686.1 PH domain-containing protein -
MCF40_RS09970 (2084532) 2084532..2086115 - 1584 WP_031787687.1 PH domain-containing protein -
MCF40_RS09975 (2086108) 2086108..2086587 - 480 WP_031787688.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.79 Da        Isoelectric Point: 10.2892

>T235647 WP_000621178.1 NZ_CP092072:c2082209-2081847 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

>T235647 NZ_LR134315:c2359562-2359386 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT235647 WP_000948331.1 NZ_CP092072:c2082376-2082206 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT235647 NZ_LR134315:c2359340-2358924 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCACCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References