Detailed information of TA system TA235644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1885967..1886754
• Replicon: chromosome
• Accession: NZ_CP092072
• Organism: Staphylococcus argenteus strain 1710042798

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A7U7PZK3
• Locus tag: MCF40_RS08755
• Protein ID: WP_000031103.1
• Coordinates: 1885967..1886122 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MCF40_RS08760
• Protein ID: WP_031787929.1
• Coordinates: 1886155..1886754 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCF40_RS08735 (1881155)	1881155..1882267	-	1113	WP_031787927.1	GAF domain-containing sensor histidine kinase	-
MCF40_RS08740 (1882429)	1882429..1883250	+	822	WP_000669386.1	RluA family pseudouridine synthase	-
MCF40_RS08745 (1883544)	1883544..1884929	-	1386	WP_031787928.1	class II fumarate hydratase	-
MCF40_RS08750 (1885100)	1885100..1885501	-	402	WP_000901017.1	hypothetical protein	-
MCF40_RS08755 (1885967)	1885967..1886122	-	156	WP_000031103.1	SAS053 family protein	Toxin
MCF40_RS08760 (1886155)	1886155..1886754	-	600	WP_031787929.1	glucosamine-6-phosphate isomerase	Antitoxin
MCF40_RS08765 (1886913)	1886913..1887383	-	471	WP_000181399.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MCF40_RS08770 (1887385)	1887385..1888515	-	1131	WP_031787930.1	tRNA epoxyqueuosine(34) reductase QueG	-
MCF40_RS08775 (1888666)	1888666..1889388	-	723	WP_031787931.1	amino acid ABC transporter ATP-binding protein	-
MCF40_RS08780 (1889381)	1889381..1890838	-	1458	WP_000649887.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1832169..1907621	75452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6019.42 Da
• Isoelectric Point: 4.1469

>T235644 WP_000031103.1 NZ_CP092072:c1886122-1885967 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Nucleotide

• Length: 156 bp

>T235644 NZ_LR134315:1929598-1929701 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22447.58 Da
• Isoelectric Point: 5.7220

>AT235644 WP_031787929.1 NZ_CP092072:c1886754-1886155 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEHGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT235644 NZ_LR134315:c1929739-1929471 [Escherichia coli]
AAAGTCAGCGAAGGGAATGTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Toxin

• AlphaFold DB: A0A7U7PZK3