Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 863359..863836 Replicon chromosome
Accession NZ_CP092072
Organism Staphylococcus argenteus strain 1710042798

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag MCF40_RS04000 Protein ID WP_000172413.1
Coordinates 863359..863547 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag MCF40_RS04005 Protein ID WP_000790107.1
Coordinates 863576..863836 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCF40_RS03970 (858939) 858939..859421 + 483 WP_031788350.1 hypothetical protein -
MCF40_RS03975 (859764) 859764..860432 + 669 WP_031788100.1 thermonuclease family protein -
MCF40_RS03980 (860796) 860796..860996 + 201 WP_001059082.1 cold-shock protein -
MCF40_RS03985 (861609) 861609..861821 - 213 WP_001007088.1 hypothetical protein -
MCF40_RS03990 (861882) 861882..862166 - 285 WP_031788101.1 hypothetical protein -
MCF40_RS03995 (862255) 862255..862824 - 570 WP_031788102.1 lipoprotein N-acylation protein LnsA -
MCF40_RS04000 (863359) 863359..863547 - 189 WP_000172413.1 hypothetical protein Toxin
MCF40_RS04005 (863576) 863576..863836 - 261 WP_000790107.1 hypothetical protein Antitoxin
MCF40_RS04010 (864176) 864176..864379 + 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
MCF40_RS04015 (864376) 864376..864612 - 237 WP_000368686.1 hypothetical protein -
MCF40_RS04020 (864837) 864837..865418 + 582 WP_031788103.1 histidine phosphatase family protein -
MCF40_RS04025 (865485) 865485..866102 - 618 WP_031788104.1 LysE family transporter -
MCF40_RS04030 (866266) 866266..866757 - 492 WP_000695603.1 GNAT family N-acetyltransferase -
MCF40_RS04035 (867164) 867164..867586 - 423 WP_001007646.1 organic hydroperoxide resistance protein -
MCF40_RS04040 (867735) 867735..868454 + 720 WP_047451209.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T235643 WP_000172413.1 NZ_CP092072:c863547-863359 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T235643 NZ_LR134315:1766953-1767207 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT235643 WP_000790107.1 NZ_CP092072:c863836-863576 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT235643 NZ_LR134315:1766705-1766956 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References