Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4523807..4525392 Replicon chromosome
Accession NZ_CP092070
Organism Pectobacterium sp. PL64

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HP572_RS20375 Protein ID WP_240584170.1
Coordinates 4524073..4525392 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HP572_RS20370 Protein ID WP_240585791.1
Coordinates 4523807..4524073 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP572_RS20345 (HP572_20345) 4519210..4519761 + 552 WP_240584166.1 TetR/AcrR family transcriptional regulator -
HP572_RS20350 (HP572_20350) 4519807..4520202 - 396 WP_095993289.1 helix-turn-helix domain-containing protein -
HP572_RS20355 (HP572_20355) 4520330..4521181 + 852 WP_240584167.1 SDR family oxidoreductase -
HP572_RS20360 (HP572_20360) 4521275..4522159 - 885 WP_240584168.1 LysR substrate-binding domain-containing protein -
HP572_RS20365 (HP572_20365) 4522372..4523508 + 1137 WP_240584169.1 alpha/beta hydrolase -
HP572_RS20370 (HP572_20370) 4523807..4524073 + 267 WP_240585791.1 helix-turn-helix domain-containing protein Antitoxin
HP572_RS20375 (HP572_20375) 4524073..4525392 + 1320 WP_240584170.1 type II toxin-antitoxin system HipA family toxin Toxin
HP572_RS20380 (HP572_20380) 4525425..4526789 - 1365 WP_205549514.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
HP572_RS20385 (HP572_20385) 4526919..4528553 - 1635 WP_240584171.1 membrane protein insertase YidC -
HP572_RS20390 (HP572_20390) 4528556..4528813 - 258 WP_010281237.1 membrane protein insertion efficiency factor YidD -
HP572_RS20395 (HP572_20395) 4528777..4529136 - 360 WP_010281235.1 ribonuclease P protein component -
HP572_RS20400 (HP572_20400) 4529155..4529295 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49219.40 Da        Isoelectric Point: 6.5565

>T235640 WP_240584170.1 NZ_CP092070:4524073-4525392 [Pectobacterium sp. PL64]
MAVLDVYMNGYRVGVLTKTGSGAHHFTYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDAEDDFRISIAGAQEKTA
LLYLDDHWCLPSNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKVVGFARESMENILVEFAHTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T235640 NZ_LR134315:1043819-1044130 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9900.15 Da        Isoelectric Point: 9.7281

>AT235640 WP_240585791.1 NZ_CP092070:4523807-4524073 [Pectobacterium sp. PL64]
MKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNADNTNNEASV
ASAWKEEW

Download         Length: 267 bp

>AT235640 NZ_LR134315:1044127-1044546 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAAAGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References