Detailed information of TA system TA235639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4377513..4378048
• Replicon: chromosome
• Accession: NZ_CP092070
• Organism: Pectobacterium sp. PL64

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HP572_RS19705
• Protein ID: WP_174866994.1
• Coordinates: 4377761..4378048 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6DB37
• Locus tag: HP572_RS19700
• Protein ID: WP_010281712.1
• Coordinates: 4377513..4377764 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP572_RS19675 (HP572_19675)	4373591..4374028	+	438	WP_205543697.1	RICIN domain-containing protein	-
HP572_RS19680 (HP572_19680)	4374352..4374630	+	279	WP_240584101.1	substrate-binding domain-containing protein	-
HP572_RS19685 (HP572_19685)	4374674..4375297	-	624	WP_240584102.1	LysE family translocator	-
HP572_RS19690 (HP572_19690)	4375564..4376319	+	756	WP_240584103.1	thiol:disulfide interchange protein DsbG	-
HP572_RS19695 (HP572_19695)	4376353..4377258	-	906	WP_240584104.1	siderophore-interacting protein	-
HP572_RS19700 (HP572_19700)	4377513..4377764	+	252	WP_010281712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HP572_RS19705 (HP572_19705)	4377761..4378048	+	288	WP_174866994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HP572_RS19710 (HP572_19710)	4378150..4379502	-	1353	WP_010296544.1	glutathione-disulfide reductase	-
HP572_RS19715 (HP572_19715)	4379631..4380473	-	843	WP_039316638.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
HP572_RS19720 (HP572_19720)	4380765..4381148	-	384	WP_240584105.1	TfoX/Sxy family protein	-
HP572_RS19725 (HP572_19725)	4381270..4382625	-	1356	WP_240584106.1	alkyl/aryl-sulfatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11143.26 Da
• Isoelectric Point: 10.4703

>T235639 WP_174866994.1 NZ_CP092070:4377761-4378048 [Pectobacterium sp. PL64]
MSYRVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Nucleotide

• Length: 288 bp

>T235639 NZ_LR134315:970875-971210 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9117.47 Da
• Isoelectric Point: 4.0637

>AT235639 WP_010281712.1 NZ_CP092070:4377513-4377764 [Pectobacterium sp. PL64]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT235639 NZ_LR134315:970627-970875 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0M2EZP0