Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 706541..707167 Replicon chromosome
Accession NZ_CP092070
Organism Pectobacterium sp. PL64

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag HP572_RS03060 Protein ID WP_005976087.1
Coordinates 706541..706744 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag HP572_RS03065 Protein ID WP_010282247.1
Coordinates 706799..707167 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP572_RS03030 (HP572_03030) 702016..702354 + 339 WP_205552781.1 P-II family nitrogen regulator -
HP572_RS03035 (HP572_03035) 702394..703681 + 1288 Protein_594 ammonium transporter AmtB -
HP572_RS03040 (HP572_03040) 703820..704683 - 864 WP_205552777.1 acyl-CoA thioesterase II -
HP572_RS03045 (HP572_03045) 704896..705477 + 582 WP_240584752.1 YbaY family lipoprotein -
HP572_RS03050 (HP572_03050) 705497..705817 - 321 WP_010282239.1 MGMT family protein -
HP572_RS03060 (HP572_03060) 706541..706744 - 204 WP_005976087.1 HHA domain-containing protein Toxin
HP572_RS03065 (HP572_03065) 706799..707167 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
HP572_RS03070 (HP572_03070) 707766..707909 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
HP572_RS03075 (HP572_03075) 707927..708175 - 249 WP_240584753.1 type B 50S ribosomal protein L31 -
HP572_RS03080 (HP572_03080) 708409..711538 - 3130 Protein_602 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T235632 WP_005976087.1 NZ_CP092070:c706744-706541 [Pectobacterium sp. PL64]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T235632 NZ_LR134313:2444585-2444851 [Neisseria canis]
ATGAAAGCGATTGAGTTCAGTAACGCATTCAAACGCGATTTCAAAAAATATCCTGCGCTGGCGCTGTCAACGCGCTGGAT
TGAAGCACTCTACTGTATATGCAGCGAACAAACTCTGCCGCCTAAATTTTGCGACCACGCACTCACGGGCAACTGGCACG
GCTTTCGCGACTGCCACATCGAGCCTGATTTGGTGCTGATTTACCGCCATACGGAAAACACAGTCGAACTGGCACGAATC
GGCACGCACTCCGCGCTGTTCGGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT235632 WP_010282247.1 NZ_CP092070:c707167-706799 [Pectobacterium sp. PL64]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT235632 NZ_LR134313:2444332-2444598 [Neisseria canis]
ATGGCTGCCAATGCACTTGTGAGCGTACGCATCAACGAAGATGTGAAAAACCAAGCCAGCGCAGTATTGGCCGGTGCGGG
TTTGACCATCTCCGACGTCATCCGCATGACGCTGACCAAAATCGCCACCGAGCAACGCTTCAGCTTCGACTACCAACCCA
ACGCCGAAACCGCACGCGTTTTAACTGCCATGCAAAACGGCACGGAAACCCTGCATCGCGCCGACAGTGTGGAAGCATTG
ATGGAACGGCTGAATGAAAGCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References