Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 216952..217612 Replicon chromosome
Accession NZ_CP092070
Organism Pectobacterium sp. PL64

Toxin (Protein)


Gene name cptA Uniprot ID A0A837DIN4
Locus tag HP572_RS01020 Protein ID WP_039275532.1
Coordinates 217199..217612 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag HP572_RS01015 Protein ID WP_005971623.1
Coordinates 216952..217218 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP572_RS00995 (HP572_00995) 212916..213920 - 1005 WP_240584528.1 LacI family DNA-binding transcriptional regulator -
HP572_RS01000 (HP572_01000) 213975..214583 - 609 WP_240584529.1 HD domain-containing protein -
HP572_RS01005 (HP572_01005) 215013..215660 + 648 WP_240584530.1 hemolysin III family protein -
HP572_RS01010 (HP572_01010) 215715..216716 - 1002 WP_240584531.1 tRNA-modifying protein YgfZ -
HP572_RS01015 (HP572_01015) 216952..217218 + 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
HP572_RS01020 (HP572_01020) 217199..217612 + 414 WP_039275532.1 protein YgfX Toxin
HP572_RS01025 (HP572_01025) 217681..218616 + 936 WP_240584532.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
HP572_RS01030 (HP572_01030) 218682..219005 - 324 WP_240584533.1 hypothetical protein -
HP572_RS01035 (HP572_01035) 219034..219552 - 519 WP_240584534.1 flavodoxin FldB -
HP572_RS01040 (HP572_01040) 219881..220267 - 387 WP_039282122.1 thioesterase family protein -
HP572_RS01045 (HP572_01045) 220512..221840 - 1329 WP_039534583.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16311.26 Da        Isoelectric Point: 10.7911

>T235630 WP_039275532.1 NZ_CP092070:217199-217612 [Pectobacterium sp. PL64]
VAQWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Download         Length: 414 bp

>T235630 NZ_LR134313:c500831-500553 [Neisseria canis]
ATGATTCAAACTTTTAACTGCAAACACACCGAGCAGCTGTTCCAAGGTCGCTGCCCATTGAAATTCAGGGCTATCCGAAA
GACAGCGGAGCGCAAACTGCAAATGTTGGATTCTGCCGTTACTGTGGATTTTCTGCGTTCCCCGCCCGGCAACAGACTTG
AAGCACTCAAAGGCAGCCGTACCGGACAGTTCAGCATCCGCATCAATGACCAATGGCGGGTTTGCTTCCGTTTTGAAAAC
GGTCATGCCTACGATGTTGAAATTGTCGATTACCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT235630 WP_005971623.1 NZ_CP092070:216952-217218 [Pectobacterium sp. PL64]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT235630 NZ_LR134313:c500543-500250 [Neisseria canis]
ATGAATAACCAAATGAGACCCATACACCCCGGCGAAATTTTGCGCGAAGAATACCTGATTCCGCTGGGTATAACGGCCAA
TGCCCTGTCTGTTGCCCTGCATGTTCCCGCACCGCGCATTAACGACATCGTGCGCGAAAAGCGGGGCATCAGTCCCGACA
CCGCCTTGCGGCTTGCCCGCTATTTCGGCGGCGATGCACAAAGCTGGCTGAACCTGCAAAACGCCTACGATCTGAAAGTG
GCGGAACAGTCTCTGAAACAGGAAATCGACCACATTATCCCTATGCAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837DIN4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References