Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 585430..586022 Replicon chromosome
Accession NZ_CP092062
Organism Edwardsiella ictaluri strain S00-1912

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MAY76_RS02905 Protein ID WP_012847872.1
Coordinates 585819..586022 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag MAY76_RS02900 Protein ID WP_015870487.1
Coordinates 585430..585798 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAY76_RS02890 (MAY76_02880) 580690..581874 + 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -
MAY76_RS02895 (MAY76_02885) 581918..585070 + 3153 WP_015870488.1 efflux RND transporter permease subunit -
MAY76_RS02900 (MAY76_02890) 585430..585798 + 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
MAY76_RS02905 (MAY76_02895) 585819..586022 + 204 WP_012847872.1 HHA domain-containing protein Toxin
MAY76_RS02910 (MAY76_02900) 586042..586149 - 108 Protein_555 IS5/IS1182 family transposase -
MAY76_RS02920 (MAY76_02910) 587125..587454 + 330 WP_015870485.1 MGMT family protein -
MAY76_RS02925 (MAY76_02915) 587500..588366 + 867 WP_015870484.1 acyl-CoA thioesterase II -
MAY76_RS02930 (MAY76_02920) 588400..589680 - 1281 WP_035610376.1 ammonium transporter AmtB -
MAY76_RS02935 (MAY76_02925) 589702..590040 - 339 WP_015870482.1 P-II family nitrogen regulator -
MAY76_RS02940 (MAY76_02930) 590338..590800 - 463 Protein_560 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T235618 WP_012847872.1 NZ_CP092062:585819-586022 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T235618 NZ_LR134311:c4174019-4173645 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT235618 WP_015870487.1 NZ_CP092062:585430-585798 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT235618 NZ_LR134311:c4174477-4174109 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References