Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1835352..1836128 Replicon chromosome
Accession NZ_CP092055
Organism Staphylococcus aureus strain USA600

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag AH5611_RS08790 Protein ID WP_000031109.1
Coordinates 1835352..1835504 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag AH5611_RS08795 Protein ID WP_001251224.1
Coordinates 1835529..1836128 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH5611_RS08775 (1831330) 1831330..1832151 + 822 WP_000669377.1 RluA family pseudouridine synthase -
AH5611_RS08780 (1832608) 1832608..1833993 - 1386 WP_238762290.1 class II fumarate hydratase -
AH5611_RS08785 (1834189) 1834189..1834584 - 396 WP_000901019.1 hypothetical protein -
AH5611_RS08790 (1835352) 1835352..1835504 - 153 WP_000031109.1 SAS053 family protein Toxin
AH5611_RS08795 (1835529) 1835529..1836128 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
AH5611_RS08800 (1836287) 1836287..1836757 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
AH5611_RS08805 (1836762) 1836762..1837889 - 1128 WP_000379990.1 tRNA epoxyqueuosine(34) reductase QueG -
AH5611_RS08810 (1838040) 1838040..1838762 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
AH5611_RS08815 (1838755) 1838755..1840211 - 1457 Protein_1727 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5950.31 Da        Isoelectric Point: 3.9075

>T235611 WP_000031109.1 NZ_CP092055:c1835504-1835352 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Download         Length: 153 bp

>T235611 NZ_LR134311:2684241-2684348 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT235611 WP_001251224.1 NZ_CP092055:c1836128-1835529 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT235611 NZ_LR134311:c2684194-2684128 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References