235604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2138911..2139425 Replicon chromosome
Accession NZ_CP092052
Organism Staphylococcus aureus strain USA300

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag AH5667_RS10695 Protein ID WP_000581792.1
Coordinates 2138911..2139120 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag AH5667_RS10700 Protein ID WP_000138932.1
Coordinates 2139132..2139425 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH5667_RS10675 (2134419) 2134419..2135777 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AH5667_RS10680 (2135792) 2135792..2136862 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
AH5667_RS10685 (2137180) 2137180..2138382 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
AH5667_RS10690 (2138646) 2138646..2138783 - 138 WP_000828354.1 Lmo0850 family protein -
AH5667_RS10695 (2138911) 2138911..2139120 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
AH5667_RS10700 (2139132) 2139132..2139425 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
AH5667_RS10705 (2139591) 2139591..2141075 + 1485 WP_000571549.1 cardiolipin synthase -
AH5667_RS10710 (2141103) 2141103..2141750 + 648 WP_001187629.1 HD domain-containing protein -
AH5667_RS10715 (2142563) 2142563..2143435 - 873 WP_000725802.1 membrane protein insertase YidC -
AH5667_RS10720 (2143521) 2143521..2144162 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T235604 WP_000581792.1 NZ_CP092052:c2139120-2138911 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T235604 NZ_LR134311:990071-990478 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT235604 WP_000138932.1 NZ_CP092052:c2139425-2139132 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT235604 NZ_LR134311:989824-990090 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References