Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1918518..1919294 Replicon chromosome
Accession NZ_CP092052
Organism Staphylococcus aureus strain USA300

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag AH5667_RS09340 Protein ID WP_000031108.1
Coordinates 1918518..1918670 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag AH5667_RS09345 Protein ID WP_001251224.1
Coordinates 1918695..1919294 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH5667_RS09325 (1914481) 1914481..1915302 + 822 WP_000669376.1 RluA family pseudouridine synthase -
AH5667_RS09330 (1915765) 1915765..1917150 - 1386 WP_000116224.1 class II fumarate hydratase -
AH5667_RS09335 (1917346) 1917346..1917741 - 396 WP_000901021.1 hypothetical protein -
AH5667_RS09340 (1918518) 1918518..1918670 - 153 WP_000031108.1 SAS053 family protein Toxin
AH5667_RS09345 (1918695) 1918695..1919294 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
AH5667_RS09350 (1919453) 1919453..1919923 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
AH5667_RS09355 (1919928) 1919928..1921055 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
AH5667_RS09360 (1921206) 1921206..1921928 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
AH5667_RS09365 (1921921) 1921921..1923378 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T235598 WP_000031108.1 NZ_CP092052:c1918670-1918518 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T235598 NZ_LR134309:c5538681-5538382 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT235598 WP_001251224.1 NZ_CP092052:c1919294-1918695 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT235598 NZ_LR134309:c5538385-5538095 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References