235595

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 829063..829540 Replicon chromosome
Accession NZ_CP092052
Organism Staphylococcus aureus strain USA300

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag AH5667_RS03990 Protein ID WP_000052078.1
Coordinates 829063..829251 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AH5667_RS03995 Protein ID WP_001059690.1
Coordinates 829280..829540 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH5667_RS03960 (825104) 825104..825574 + 471 WP_000824472.1 hypothetical protein -
AH5667_RS03965 (825915) 825915..826601 + 687 WP_001548082.1 thermonuclease family protein -
AH5667_RS03970 (826958) 826958..827158 + 201 WP_001059082.1 cold-shock protein -
AH5667_RS03975 (827654) 827654..827872 - 219 WP_000005886.1 hypothetical protein -
AH5667_RS03980 (827934) 827934..828218 - 285 WP_001004395.1 hypothetical protein -
AH5667_RS03985 (828306) 828306..828875 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
AH5667_RS03990 (829063) 829063..829251 - 189 WP_000052078.1 hypothetical protein Toxin
AH5667_RS03995 (829280) 829280..829540 - 261 WP_001059690.1 hypothetical protein Antitoxin
AH5667_RS04000 (829881) 829881..830084 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AH5667_RS04005 (830081) 830081..830317 - 237 WP_000368687.1 hypothetical protein -
AH5667_RS04010 (830542) 830542..831123 + 582 WP_001140686.1 histidine phosphatase family protein -
AH5667_RS04015 (831196) 831196..831813 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
AH5667_RS04020 (831968) 831968..832462 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AH5667_RS04025 (832861) 832861..833283 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AH5667_RS04030 (833431) 833431..834147 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T235595 WP_000052078.1 NZ_CP092052:c829251-829063 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T235595 NZ_LR134309:c4658177-4657422 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT235595 WP_001059690.1 NZ_CP092052:c829540-829280 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT235595 NZ_LR134309:c4658680-4658312 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCTTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References